Quality of Anticoagulation With Warfarin in Patient With Atrial Fibrillation for Secondary Stroke Prevention in Korea

• To assess the quality of anticoagulation with warfarin in real world practice of Korea for secondary stroke prevention in patients with AF-related Cardioembolic (CE) stroke 1) who initiated warfarin therapy and treatment at least for more than 7 days of warfarin adjustment period (warfarin-initiated cohort), and 2) who initiated and maintained warfarin therapy at least for more than 90 days after the 7 days of warfarin adjustment period (long-term warfarin-treated cohort).
• To explore predictors for poor INR control.

Inclusion criteria

Inclusion criteria

for the warfarin-initiated cohort

• Admission due to AF-related ischemic stroke
• Initiation of warfarin therapy and treatment at least for more than 7 days of warfarin adjustment period
• For TTR calculation, available consecutive INR values ≥3 after the 7 days of warfarin adjustment

Inclusion criteria

for the long-term warfarin-treated cohort

• Admission due to AF-related ischemic stroke
• Long-term warfarin therapy at least for more than 90 days after the 7 days of warfarin adjustment period
• For TTR calculation, available consecutive INR values ≥3 after the 7 days of warfarin adjustment
• TTR evaluable days ≥ 90 days

Exclusion criteria

• AF with mechanical valve
• Enrollment in anticoagulation randomized clinical trial
• Enrollment in studies affecting the target INR range.