Qualitative and Functional Investigation of Lipids in Patients With SARS-CoV2 Infection - In Search of Atherogenic Sequelae

Inclusion criteria

Participants with a history of asymptomatic/mildly symptomatic SARS-CoV2 infection:

• Age ≥18 years
• Participant who has provided consent
• Participant affiliated to National health insurance
• Participant with asymptomatic or minimally symptomatic SARS CoV2 infection who did not require hospitalization at least 6 months prior to study inclusion.
• SARS CoV2 infection proven by positive PCR or antigenic test at the time of signs of infection or positive SARS-CoV2 infection-specific serology at the time of infection (IgG+).

Participants with a history of symptomatic SARS-CoV2 infection hospitalized at the Dijon University Hospital excluding the intensive care unit:

• Age ≥18 years
• Participant having provided consent
• Participant affiliated to National health insurance
• Participant having presented a symptomatic SARS CoV2 infection requiring admission to a regular hospital unit at least 6 months prior to inclusion in the study.
• SARS CoV2 infection proven by a positive PCR or antigenic test at the time of signs of infection or a positive SARS-CoV2 specific serology at the time of infection (IgG+).

Participants with a history of symptomatic SARS-CoV2 infection hospitalized at Dijon University Hospital in the ICU:

• Age ≥18 years
• Participant who has provided consent
• Participant affiliated to National health insurance
• Participant with symptomatic SARS CoV2 infection requiring admission to an intensive care unit at least 6 months prior to study inclusion.
• SARS CoV2 infection proven by a positive PCR or antigenic test at the time of signs of infection or a positive SARS-CoV2 specific serology at the time of infection (IgG+).

Participants with no history of SARS-CoV2 infection:

• Age≥18 years
• Participant who has provided consent
• Participant affiliated to National health insurance
• Participant with no evidence of SARS CoV2 infection and negative SARS-CoV2 serology.
• For vaccinated participants: negative specific serology for SARS-CoV2 infection

Exclusion criteria

For all participants:

• SARS Cov2 vaccination within one month prior to inclusion.
• Previous SARS Cov1 infection documented
• Previous study participant
• Participant under legal protection (guardianship)
• Participant subject to a legal protection measure
• A protected adult
• Pregnant, parturient or breastfeeding women
• Treatment with corticosteroids in the last year
• Treatment with lipid-lowering drugs
• Known genetic mutation modifying HDL cholesterol
• Progressive neoplasia
• Chronic alcoholism
• Primary biliary cirrhosis
• Hyperthyroidism
• Unstable hypothyroidism
• History of cardiac or cardiovascular side effects following SARS-CoV2 vaccination (thrombosis, myocarditis etc)

For participants with a history of asymptomatic/mildly symptomatic SARS-CoV2 infection:

• Hospitalization with a prior SARS-CoV2 infection in a conventional or intensive care unit

For participants with a history of symptomatic SARS-CoV2 infection hospitalized outside the ICU:

• Previous ICU hospitalization for SARS-CoV2 infection

For participants with no history of SARS-CoV2 infection:

• Previous positive SARS-CoV2 PCR
• Negative SARS-CoV2 PCR and presence of clinical symptoms suggestive of SARS-CoV2 infection
• Previous positive serology for SARS-CoV2 infection

Secondary exclusion criteria :

For healthy volunteers with no history of SARS-CoV2 infection:

Positive specific serology for SARS-CoV2 infection at the screening visit.