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NCT Number: NCT07695987

Quadro-Iliac Plane Block for Analgesia After Lumbar Microdiscectomy

This study will evaluate whether ultrasound-guided quadro-iliac plane block provides better postoperative pain control than local infiltration analgesia in patients undergoing single-level lumbar microdiscectomy.

Adult patients scheduled for elective single-level lumbar microdiscectomy will be randomly assigned to receive either bilateral quadro-iliac plane block plus patient-controlled analgesia or local infiltration analgesia plus patient-controlled analgesia. The main outcome of the study will be total fentanyl consumption during the first 24 hours after surgery. Pain scores, need for rescue analgesia, opioid-related side effects, patient satisfaction, and recovery quality will also be evaluated.

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Key information

Conditions

Pain Management Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital

Istanbul, 34303, Turkey (Türkiye)

Location status: Recruiting

Location contact

Engin ihsan Turan

CONTACT

[email protected]

05382431114

About this study

This is a prospective, randomized, double-blind, controlled, multicenter clinical trial designed to assess the analgesic efficacy of ultrasound-guided quadro-iliac plane block in patients undergoing elective single-level lumbar microdiscectomy.

Patients aged 18-75 years with American Society of Anesthesiologists physical status I-III who are scheduled for elective single-level lumbar microdiscectomy under general anesthesia will be included. Participants will be randomized into two groups. The intervention group will receive bilateral ultrasound-guided quadro-iliac plane block before emergence from anesthesia, followed by postoperative patient-controlled analgesia. The control group will receive local infiltration analgesia performed by the surgeon, followed by postoperative patient-controlled analgesia.

All patients will receive a standardized general anesthesia protocol. Postoperative analgesia will be provided using a fentanyl-based patient-controlled analgesia device. The primary outcome will be total fentanyl consumption during the first postoperative 24 hours. Secondary outcomes will include numerical rating scale pain scores at predefined postoperative time points, rescue analgesic requirement, opioid-related adverse effects such as nausea, vomiting, pruritus and respiratory depression, dermatomal sensory spread, and patient-reported recovery quality using the QoR-15 questionnaire.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 to 75 years
  • American Society of Anesthesiologists physical status I to III
  • Scheduled for elective single-level lumbar microdiscectomy, such as L4-L5 or L5-S1 disc herniation
  • Planned surgery under general anesthesia
  • Able to provide written informed consent

Exclusion criteria

  • Allergy or hypersensitivity to local anesthetics
  • Coagulopathy or active anticoagulant use
  • Infection, scar tissue, or skin lesion at the injection site
  • Pregnancy or breastfeeding
  • Chronic pain syndrome or regular opioid use
  • American Society of Anesthesiologists physical status IV or higher
  • Planned surgery for two or more levels of disc herniation

Treatment and study plan

Ultrasound-Guided Quadro-Iliac Plane Block

Procedure

Bilateral ultrasound-guided quadro-iliac plane block will be performed before emergence from general anesthesia in the prone position. After visualization of the quadratus lumborum muscle and iliac crest at the L3 level, 30 mL of 0.167% bupivacaine will be injected into the interfascial plane on each side. All participants will receive postoperative fentanyl-based patient-controlled analgesia.

Local Infiltration Analgesia (LIA)

Procedure

Local infiltration analgesia will be performed by the surgeon before the end of surgery. A total dose of 50 mg of 0.25% bupivacaine will be infiltrated into the subcutaneous tissue. All participants will receive postoperative fentanyl-based patient-controlled analgesia.

Primary outcomes

  1. Total Fentanyl Consumption During the First 24 Hours After Surgery

    Time frame: Postoperative 0-24 hours

    Total postoperative fentanyl consumption administered via patient-controlled analgesia will be recorded during the first 24 hours after surgery.

Secondary outcomes

  1. Postoperative Pain Scores at Rest and During Movement

    Time frame: Postoperative 0, 1, 6, 12, and 24 hours

    Pain intensity will be assessed using the Numerical Rating Scale at rest and during movement. The scale ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain.

  2. Number of Patients Require Rescue Analgesic

    Time frame: Postoperative 0-24 hours

    The need for rescue analgesia with intravenous tenoxicam will be recorded during the postoperative follow-up period.

  3. Opioid-Related Adverse Effects

    Time frame: Postoperative 0-24 hours

    Opioid-related adverse effects, including nausea, vomiting, pruritus, and respiratory depression, will be recorded.

  4. Quality of Recovery Score

    Time frame: Postoperative 24 hours

    Patient-reported recovery quality will be assessed using the Quality of Recovery-15 questionnaire (0-150). Higher value means better Quality of Recovery.

  5. Dermatomal Sensory Spread

    Time frame: Postoperative 2 hours

    Dermatomal sensory spread of the block will be evaluated using a cold test.

Study contacts

Contact information is provided by the study sponsor or research team.

Engin ihsan Turan, principal investigator

CONTACT

[email protected]

+905382431114

Sponsors and collaborators

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital

Other

Registry information

Official study title

Effect of Ultrasound-Guided Quadro-Iliac Plane Block Compared With Local Infiltration Analgesia After Single-Level Lumbar Microdiscectomy: A Prospective, Double-Blind, Controlled, Multicenter Randomized Trial

Acronym: QIPB RCT

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 10, 2026
Registry last updated
Jul 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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