QT Variability Pre and Post Cardioversion

The purpose of this study is to learn whether the chemicals in the blood and urine are different when the heart is atrial fibrillation compared to normal sinus rhythm.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

21 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Vanderbilt University Medical Center

Nashville, Tennessee, 37232-0575, United States

About this study

Atrial Fibrillation variably activates the renin-angiotensin-aldosterone system (RAAS), stimulates the sympathetic nervous system, generates oxidant stress, produces natriuretic peptides, and increases ventricular rate. These are interrelated responses and the extent to which these or other pathophysiologic responses determine QT interval during and after Atrial Fibrillation (AF) is unknown. In this study, the QT variability is related to those potential markers in patients with AF undergoing elective DC-cardioversion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

At least 21 years of age
Scheduled to undergo an elective DC-Cardioversion of atrial fibrillation or atrial flutter at Vanderbilt University Medical Center

Exclusion criteria

Undergoing emergent DC-Cardioversion of atrial fibrillation for hemodynamic instability
Undergoing DC-Cardioversion for post-cardiac surgery
Dual chamber pacemakers

Treatment and study plan

Primary outcomes

QT variability before and after direct current cardioversion

Time frame: 1.5

Sponsors and collaborators

Lead sponsor

Vanderbilt University

Other

Collaborators

National Institutes of Health (NIH)
Wake Forest University Health Sciences

Registry information

Official study title

QT Variability Pre & Post Cardioversion in Patient's With Atrial Fibrillation

Acronym: DCCV

Important dates

Study start: 2007
Primary completion: 2012
Study completion: 2012
First posted: Apr 22, 2009
Registry last updated: Dec 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed