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Completed

NCT Number: NCT03529201

QLB After Nephrectomy

Oxycodone consumption and postoperative pain intensity in patients undergoing nephrectomy procedures. Of all study participants, 50% will obtain quadratus lumborum block (QLB).

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Key information

Conditions

Pain, Postoperative Chronic Postoperative Pain Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesiology and Intensive Care, J. Śniadecki Hospital in Białystok, Bialystok, Poland

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About this study

Patients undergoing nephrectomy procedures will be allocated to one of the study arms. At the end of an operation, still under general anesthesia, 50% patients will obtain QLB with ropivacaine.

Ultrasound-guided QLB will be performed on the side of surgery with 0.375% ropivacaine solution (0.2 mL per kg).

Every patient will get patient-controlled analgesia pump with oxycodone in the postoperative period.

Postoperative pain will be measured with VAS (visual-analogue scale) 2, 4, 8, 12 and 24 hours after the end of the operation. 24 -hours period.

At the 1, 3, 6 months patients will be interviewed by phone to assess neuropathic pain. Neuropathic Pain Symptom Inventory (NPSI) will be used.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • obtained consent
  • nephrectomy procedure

Exclusion criteria

  • coagulopathy allergy to local anesthetics depression, antidepressant drugs treatment epilepsy usage of painkiller before surgery addiction to alcohol or recreational drugs

Treatment and study plan

QLB

Procedure

On the side of the surgery, QLB with 0.375% ropivacaine (0.2 mL/kg)

PCA

Device

Patient-controlled analgesia

GA

Procedure

General anesthesia

Oxycodone

Drug

administered by PCA

Sevoflurane

Drug

Inhalational anesthetic during GA

Fentanyl

Drug

painkiller during GA

Rocuronium

Drug

muscle relaxant during GA

Primary outcomes

  1. Total consumption of oxycodone

    Time frame: 24 hours after the end of surgery.

    Overall use of oxycodone administered by PCA pump will be assessed.

Secondary outcomes

  1. Pain intensity

    Time frame: 24 hours after the end of surgery

    Pain intensity measured on VAS scale at the 2, 4, 8, 12, 24 hours. VAS in milimmeters. Minimum value 0, maximum 100. Less better - less severe pain. 0 no pain at all.

  2. Chronic pain

    Time frame: 6 months after the surgery

    Chronic pain occurrence assessed with Neuropathic Pain Symptom Inventory (NPSI) 10 descriptive variables, each one from 0 to 10. 0 means no pain. 10 very high chance of occurrence of neuropathic pain.

Sponsors and collaborators

Lead sponsor

Medical University of Lublin

Other

Collaborators

  • Department of Anesthesiology and Intensive Care, F. Chopin Hospital in Rzeszów
  • Department of Anesthesiology and Intensive Care, J. Śniadecki Hospital in Białystok

Registry information

Official study title

Effectiveness of Quadratus Lumborum Block After Nephrectomy

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
May 18, 2018
Registry last updated
Nov 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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