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Completed

NCT Number: NCT02457572

Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition

Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal. The investigators evaluated whether PPV measured during Valsalva maneuver can predict fluid responsiveness after sternotomy.

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Key information

Conditions

Cardiac Surgical Procedures Sternotomy Thoracic Surgical Procedures

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsung Medical Center

Seoul, 135-710, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients undergoing elective off-pump coronary arterial bypass grafting

Exclusion criteria

  • Preoperative LV EF <= 35%
  • Moderate or severe valvular heart disease
  • Cardiac arrhythmia
  • Intracardiac shunt
  • Severe renal or liver disease
  • Moderate to severe pulmonary hypertension (mean PAP > 35 mmHg)
  • Patients with bullous lung disease or combined pneumothorax

Treatment and study plan

valsalva maneuver

Procedure

Valsalva maneuver was performed after sternotomy with the constant airway pressure of 30cmH2O for 2 breaths duration.

Other names: Lung recruitment maneuver

Fluid Loading

Other

We record the cardiac index values before and after volume expansion with 6ml/kg of balanced crystalloid

Other names: Balanced crystalloid infusion

Primary outcomes

  1. Pulse pressure variation during Valsalva maneuver

    Time frame: during Valsalva maneuver

Secondary outcomes

  1. Pulse pressure variation after sternotomy

    Time frame: 5 min after sternotomy

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition in the Patients Undergoing Off-pump Coronary Arterial Bypass Grafting

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
May 29, 2015
Registry last updated
Sep 14, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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