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Completed

NCT Number: NCT02580903

Pulmonary Hypertension in Patients With Myeloproliferative Neoplasms

This is an observational prospective study aiming to clarify the prevalence of pulmonary hypertension in patients with Myeloproliferative Neoplasms and their prognosis.

All patients attending our department with the above mentioned neoplasms will be offered inclusion in this study. All will have an echo performed and patients identified as being at risk of pulmonary hypertension will be offered complete investigation as specified by the European Cardiology Association.

All patients will be followed up for a total of five years to identify prognosis.

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Key information

Conditions

Myeloproliferative Disorders Bone Marrow Diseases Cardiovascular Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hypertension Hypertension, Pulmonary Lung Diseases Pulmonary Hypertension Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Odense University Hospital

Odense, 5000, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Myeloproliferative Neoplasms (PV, ET, PMF according to WHO classification)

Exclusion criteria

  • Pregnancy
  • Lack of informed consent
  • Age < 18 years
  • Cognitive dysfunctions

Treatment and study plan

Radiology

Radiation

Only a small subsample will require CT and right heart catherisation

Primary outcomes

  1. Prevalence of pulmonary hypertension at initial presentation and first echo

    Time frame: Initial recruitment

Secondary outcomes

  1. Mortality

    Time frame: 1 and 5 years

  2. Incidence of pulmonary hypertension while under follow-up

    Time frame: 5 years

Sponsors and collaborators

Lead sponsor

Odense University Hospital

Other

Registry information

Official study title

Pulmonary Hypertension in Patients With Philadelphia Chromosome Negative Myeloproliferative Neoplasms; an Observational Prospective Study

Acronym: MPNPH

Important dates

Study start
2015
Primary completion
2018
Study completion
2020
First posted
Oct 20, 2015
Registry last updated
Sep 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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