Recruiting

NCT Number: NCT03954574

Pulmonary Hemodynamics During Exercise - Research Network

The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Pulmonary Circulation Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Royal Prince Alfred Hospital, Respiratory Medicine, Camperdown, Australia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
Written informed consent of participating subjects after being fully briefed (for prospective analysis)

Exclusion criteria

Patients with incomplete hemodynamic data at rest or exercise
Patients without sufficient follow-up data (information on survival / lung transplantation)
advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
advanced heart failure with pulmonary arterial wedge pressure (PAWP) > 18 mmHg at rest
uncontrolled systemic arterial hypertension (RR values > 160/100 mmHg at rest)
FEV1<50% predicted
TLC<60% predicted

Treatment and study plan

assessment of pulmonary hemodynamics during exercise by right heart catheterization

Diagnostic Test

all patients undergo right heart catheterization during exercise due to clinical reasons. Results of this and other Routine clinical tests will be included in the registry

Primary outcomes

Number of Participants who die during observation

Time frame: 6 years

The investigators aim to assess the prognostic relevance of pulmonary hemodynamics during exercise as assessed by right heart catheterization by using a multi-centre approach and to identify independent predictors of adverse events. Separate data sets will be analysed for the retrospective and prospective Evaluation.
Number of Participants undergoing lung Transplantation during observation

Time frame: 6 years

Occurrences of lung transplantations

Secondary outcomes

Number of Participants being hospitalized during observation

Time frame: 6 years

Number of hospitalizations
Number of Participants who develop pulmonary Hypertension as assessed by right heart catheterization

Time frame: 6 years

Diagnosis of pulmonary hypertension
Number of Participants with newly initiated pulmonary arterial Hypertension medication during observation

Time frame: 6 years

Evaluation of medication initiations

Study contacts

Contact information is provided by the study sponsor or research team.

Gabor Kovacs, MD

CONTACT

[email protected]

+43-316-385 ext. 12183

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Collaborators

European Respiratory Society

Registry information

Acronym: PEX-NET

Important dates

Study start: 2018
Primary completion: 2029
Study completion: 2029
First posted: May 17, 2019
Registry last updated: Apr 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.