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OpenTrials
Completed

NCT Number: NCT04981938

Pulmonary Function After Arterial Sleeve Lobectomy

Lung cancer is the leading cause of cancer death worldwide. Despite the evolution of medical and multimodal treatments, surgical treatment remains the curative management in the localized cancer.

Historically, in central lung tumors, pneumonectomy was the gold standard. Currently, bronchial sleeve lobectomy is recommended as first-line treatment over pneumonectomy when complete resection is possible (Grade 2C).

In the case of pulmonary artery invasion, lobectomy with arterial resection and reconstruction is now an accepted option for central localized cancer.

Despite surgical challenge, arterial sleeve lobectomy is oncologically comparable with pneumonectomy while avoiding the high morbi-mortality.

Indeed, this surgery has shown better results than pneumonectomy in terms of overall survival, post-operative mortality, and quality of life.

Initially performed in patients with impaired cardio-pulmonary reserves, this parenchymal sparing procedure can be realised in all patients, when anatomical conditions allow a complete resection.

In the literature, no study has yet specifically investigated postoperative respiratory function after arterial sleeve lobectomy.

The investigators designed a retrospective monocentric study at the University Hospital of Montpellier on 81 lobectomies with pulmonary artery sleeve resection for lung cancer, from January 2001 to December 2020.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

NGUYEN

Montpellier, 34000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all major lung resection with pulmonary artery reconstruction for lung cancer
  • from January 2001 to December 2020 at University Hospital of Montpellier
  • patient > 18 years

Exclusion criteria

0

Treatment and study plan

Lobectomy with pulmonary artery reconstruction

Procedure

Lobectomy with pulmonary artery reconstruction under general anesthesia with selective intubation, by postero-lateral thoracotomy in the fifth intercostal space

Subgroups : different types of pulmonary artery reconstruction such as :

  • Tangential vascular reconstruction with direct suture
  • Circumferential resection and end-to-end anastomosis
  • bypass reconstruction with heterologous biografts, synthetic grafts, or pericardium patch

Primary outcomes

  1. Impact of pulmonary artery reconstruction on perfusion on the remaining lung lobe (ventilation/perfusion scan)

    Time frame: 2001-2020

    Comparison of perfusion data on pre and post operative ventilation/perfusion scan

Secondary outcomes

  1. Impact of pulmonary artery reconstruction on pulmonary function

    Time frame: 2001-2020

    Comparison of post operative predicted FEV1 to post operative FEV1

  2. pulmonary artery reconstruction patency

    Time frame: 2001-2020

    Patency data of the arterial reconstruction (thoracic angioscan)

  3. Pulmonary function according to the type of reconstruction

    Time frame: 2001-2020

    Comparison of the results (FEV1 ans patency) according to the type of reconstruction

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional Universitaire Montpellier

Other

Registry information

Official study title

Perfusion and Functional Results After Pulmonary Artery Reconstruction During Oncologic Lung Resection

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jul 29, 2021
Registry last updated
Sep 17, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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