PTCY Plus uhCG/EGF for Graft Versus Host Disease Prophylaxis

Inclusion criteria

• Patients with hematologic malignancy who have the indication for Allogeneic SCT and have no MRD or MUD.
• Age 18-70 years old
• Performance score of at least 80% by Karnofsky
• Adequate kidney and liver function as demonstrated by:

• Creatinine clearance should be >60 ml/min
• Total Bilirubin <1.5, ALT/AST/Alk Phos < 2.5 x normal. No evidence of chronic active hepatitis or cirrhosis.
• Negative Beta HCG test in a woman with childbearing potential, defined as not post-menopausal for 12 months or no previous surgical sterilization. Women of childbearing potential must be willing to use an effective contraceptive measure while on study.
• Patient or patient's legal representative, parent(s) or guardian able to sign informed consent.

Exclusion criteria

• Positive for HIV, HBsAg, HCV or other viral hepatitis or cirrhosis from any cause
• Active or prior CNS leukemia, unless in complete remission for at least 2 months.
• History of serious chronic mental disorder or drug-abuse accompanied by documented problems of compliance with therapeutic programs.
• Uncontrolled infection
• Donor specific antibodies
• Ejection fraction <40% or history of heart failure or cardiovascular disease
• history thrombosis or current thrombosis, family history of thrombosis, severe obesity, or thrombophilia.
• Previous history hormone responsive cancer
• history of seizure
• history of migraine or severe headache
• history of asthma
• history of uterine fibroid