Psychophysical Characterization and Brain Correlates of Dentine Hypersensitivity

Up to date, devices capable of delivering controlled, calibrated, non-contact cold air stimuli in a MR environment are unavailable for quantitative sensory testing. This project therefore aimed at designing and constructing a novel MR-compatible, computer-controlled cold air stimulation device that produces air puffs in a broad flow and cold temperature range. By means of this device, detailed psychophysically testing and subsequent brain scanning of dentine hypersensitivity (DH) subjects will be possible to gain new insights about DH mechanisms.

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Key information

Conditions

Dentine Hypersensitivity Dentin Sensitivity Stomatognathic Diseases Tooth Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Zurich, Center of Dental Medicine

Zurich, 8032, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age and between 18 - 60

Exclusion criteria

Caries
Defective restorations
Full crowns
Orthodontic bands
Bleeding on probing and periodontal pockets deeper than 3 mm
Subjects with gross periodontal disease or treatment of periodontal disease in the past 12 months.

Treatment and study plan

air puffs

Other

Primary outcomes

Subjective ratings using the BORG scale

Time frame: May 1, 2016

individual subject perception ratings will be recorded by means of an adapted BORG scale. For reliability, intraclass correlations will be used covering 3-4 measures within a 3-4-weeks period.
blood oxygenation level dependent (BOLD) response

Time frame: October 1, 2016

Changes in blood oxygenation level (indirect measure of neural activity) will be recorded

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

GlaxoSmithKline

Registry information

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2017
First posted: Oct 10, 2016
Registry last updated: Oct 27, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed