Psychobiological Markers to Improve Diagnosis and to Predict Affective Episodes in Bipolar Disorder

Inclusion criteria

For all participants:

• Participants must be capable of giving informed consent.
• Participants must be able to understand and follow the instructions in the project.
• Access to a smartphone and ability to use a smartphone and actimeter.

For patients with bipolar disorder

• Confirmed diagnosis of bipolar disorder (type 1 or type 2) according to ICD-10 after completion of an assessment at a psychiatric clinic in the Stockholm Region.
• Patients must be euthymic (stable and free from affective episodes) at the time of inclusion.
• Consent for the research team to access relevant clinical data from patient records.

For patients with recurrent depression

• Confirmed diagnosis of recurrent depression according to ICD-10 after completion of an assessment at a psychiatric clinic in Region Stockholm.
• Patients must have been referred for diagnostic assessment with the question of bipolar disorder.
• Patients must be euthymic (stable and free from affective episodes) at the time of inclusion.

Exclusion criteria

Common to all participants:

• Active substance abuse or dependence (alcohol or other substances).
• Neurological disease or cognitive impairment that may affect study results or compliance with study procedures.
• Inability to use a smartphone and smartwatch as required by the study.
• Inability to provide valid informed consent.
• Inability to understand and follow the study instructions (good knowledge of Swedish is required).

For adults without psychiatric illness:

• Current or previous psychiatric diagnosis.

For patients with bipolar disorder and patients with recurrent depression:

• Patients who are in an active affective episode (mania, hypomania or depression) at the time of recruitment.