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NCT Number: NCT06580860

Psychiatric Multi-omics and Neuroimaging Project

This study focuses on the structure and function of the brain and gene expression in peripheral blood of patients with schizophrenia, to explore the interaction and influence between the three. Patients with mental disorders who have been recruited will take their medication regularly for 1 year and participate in baseline and follow-up assessments.

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Key information

Conditions

Mental Disorders Autism Spectrum Disorder Bipolar Disorder Bipolar and Related Disorders Child Development Disorders, Pervasive Depressive Disorder Depressive Disorder, Major Healthy Control Mood Disorders Neurodevelopmental Disorders Schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders

Age range

13 year–35 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Xiangya hospital of central south univerity

Changsha, Hunan, 410000, China

Location status: Recruiting

Location contact

Yunzhi Pan

CONTACT

[email protected]

15074818197

About this study

The study seeks to identify possible biological markers of schizophrenia and the effects of gene-environment interactions on brain structural and functional networks. So we can help doctors and scientific researchers better understand the neuropathological basis of schizophrenia.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 13-35 years old(Patients with healthy siblings can be extended to 14-35 years of age)
  • Course of disease: <24 months
  • Priority is given to patients who have never taken medicine or duration of drug use < 2 weeks
  • No nuclear magnetic contraindications.

Exclusion criteria

  • Family history of psychotic disorders, history of psychoactive substances abuse, alcohol dependence, or nicotine dependence
  • Have a major physical disease or infectious disease
  • History of coma and serious neurological disease 4.MRI contraindications.

Treatment and study plan

Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids

Drug

Patients with mental disorders should take the appropriate medicine as prescribed by the doctor，and the health norms are not required to take medicine.This study will not interfere with the medication regimen of doctors.

Primary outcomes

  1. cortical morphology

    Time frame: 40 minutes

    Data were obtained using magnetic resonance scans

  2. target gene charaacteristics

    Time frame: 1 day

    10ml peripheral blood was extracted for gene analysis

  3. scale scores

    Time frame: 90 minutes.

    The score of each dimension and the total score were calculated according to the scale.The scale includes three dimensions: negative symptom, positive symptom and general psychopathology, and the score range of each dimension is different. The total score ranges from 30 to 210, with higher scores indicating worse results.

Study contacts

Contact information is provided by the study sponsor or research team.

Yunzhi Pan

CONTACT

[email protected]

15074818197

Sponsors and collaborators

Lead sponsor

mingjun Zhong

Other

Registry information

Official study title

Psychiatric Multi-omics and Neuroimaging Project Database

Acronym: PMNP

Important dates

Study start
2016
Primary completion
2027
Study completion
2027
First posted
Aug 30, 2024
Registry last updated
Mar 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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