"Pseudo-scanner" MRI Sequences for the Detection of Bone Lesions in Multiple Myeloma

Currently recommended imaging techniques for detecting bone lesions include whole-body MRI (WB-MRI), computed tomography (CT), and PET-CT. WB-MRI and PET-CT outperform CT for assessing treatment response, with WB-MRI already being the imaging modality of choice in many countries. However WB-MRI, the technique of choice for detecting bone marrow involvement, does not allow visualization of mineral bone, limiting its ability to accurately assess osteolysis. Zero Echo Time (ZTE) and Lava Flex Low Flip Angle (LF) MRI sequences represent a major advance, providing visualization of tissues at very short T2 relaxation times with resolution close to that of CT. These new sequences (known as pseudo-CT or pseudo-CT) offer for the first time the opportunity to study mineral bone by MRI, thus considerably increasing the diagnostic potential of this modality in MM.

Inclusion criteria

Patient with newly diagnosed multiple myeloma, for whom bone imaging is required for staging.

• Recurrent patient after intensive treatment (high dose chemotherapy, bone marrow transplant, etc.).
• Patient requiring a PET / CT considered as the technique of choice in these stages of the disease.

Exclusion criteria

• Implanted material incompatible with MRI.
• Severe claustrophobia.
• Pregnant women