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OpenTrials
Completed

NCT Number: NCT03734042

PRP Intrauterine Infusion in Thawed Embryo Cycles

All patients prepared to thawed embryo transfer were classified into 2 groups one group will receive platelet rich plasma (PRP) infusion intrauterine and the other group will not receive platelet rich plasma (PRP) infusion

Completed

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Key information

Conditions

Evaluations

Age range

20 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Ayman Shehata Dawood

Tanta, Egypt

About this study

Patients candidates for Thawed embryo transfer with Repeated implantation failure were recruited from 3 centers and classified into 2 groups:

Group I: Will receive platelet rich plasma (PRP) intrauterine infusion at day 11

Group II: Not receiving platelet rich plasma (PRP)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients age 20-35 years
  • Patients with previous implantation failure
  • Patients with thin endometrium<7 mm

Exclusion criteria

  • Patients older than 40 years
  • Patients with fresh embryo transfer
  • Patients with abnormal uterine cavity septate, or bicornuate uterus
  • Patients with abnormal male factor or tubal factor
  • Patients with abnormal embryos grade B or C.
  • Patients with immunological disorders as thyroidits or systemic lupus or rheumatoid arthritis

Treatment and study plan

Platelet rich plasma intrauterine infusion

Biological

platelet rich plasma will be prepared, activated then infused by Intrauterine insemination catheter intrauterine at day 11

Normal Saline

Biological

Intrauterine infusion of normal saline at day 11

Primary outcomes

  1. Endometrial thickness

    Time frame: 8 days

    The increase in endometrial thickness at day of ET

  2. Pregnancy rate

    Time frame: 15 days

    Number of cases who got pregnant

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Intrauterine Infusion of Platelet-rich Plasma Infusion Before Thawed Embryo Transfer in Repeated Implantation Failure: A Randomized Controlled Study

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Nov 7, 2018
Registry last updated
Nov 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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