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NCT Number: NCT05514769

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer. Gastroesophageal reflux disease, postoperative quality of life, short term outcomes, and long term outcomes will be compared.

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Key information

Conditions

Proximal Gastric Adenocarcinoma Deglutition Disorders Digestive System Diseases Digestive System Neoplasms Esophageal Diseases Esophageal Motility Disorders Gastric Cancer Gastroesophageal Reflux Gastroesophageal Reflux Disease Gastrointestinal Diseases Gastrointestinal Neoplasms Neoplasms Neoplasms by Site Stomach Diseases Stomach Neoplasms

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yunhong Tian

Nanchong, Sichuan, 637000, China

Location status: Recruiting

Location contact

Yunhong Tian, PHD

CONTACT

[email protected]

13508087719

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.
  • Eastern Cooperative Oncology Group performance status of 0 or 1.
  • Adequate organ function.

Exclusion criteria

  • Patients had distant metastasis.
  • oesophageal invasion of more than 3 cm.
  • Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.
  • Previous chemotherapy or radiation therapy for any other malignancies.

Treatment and study plan

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty

Procedure

The location of the anastomosis in the anterior of the gastric stump. Pyloroplasty is added in the procedure

Primary outcomes

  1. Gastroesophagus reflux disease apprised by ph monitoring

    Time frame: 6 months

    Ph monitoring by wireless or wire device

  2. Gastroesophagus reflux disease apprised by questionnaire

    Time frame: 6 months

    PGSAS-45 questionnaire is adopted.

Secondary outcomes

  1. Surgical complications of proximal gastrectomy for gastric cancer

    Time frame: 1 year

    Surgical complications include anastomotic leakage, anastomotic stricture, postoperative bleeding, pleural effusion, et al.

  2. Long-term outcome

    Time frame: 5 years

    Total survival time after proximal gastrectomy for gastric cancer

Sponsors and collaborators

Lead sponsor

Nanchong Central Hospital

Other Gov

Registry information

Important dates

Study start
2021
Primary completion
2027
Study completion
2027
First posted
Aug 24, 2022
Registry last updated
Mar 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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