Proton Radiation Therapy Registry

The Johns Hopkins Proton Therapy center is establishing a registry to capture the full 3D radiation dosimetry delivered to the patient, baseline clinical data, and disease, toxicity and quality of life outcomes. The goal is to have all patients treated at the proton center to be included in the registry to enable future comparisons of treatment outcomes to assist in understanding which patients can benefit from the use of protons.

Recruiting

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Key information

Conditions

Cancer, Therapy-Related Neoplasms Neoplasms, Second Primary

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sibley Memorial Hospital, Washington D.C., District of Columbia, United States

About this study

Proton based radiation therapy has considerable dosimetric advantages over the standard photon based radiation therapy, with a significantly higher cost. The clinical advantages, however, may not be realized for all patient populations, even with the improved dose distributions. Establishing the clinical efficacy of proton therapy requires years of experience treating patients. The goal is to accelerate the knowledge gain through the use of the registry that allows for detailed information to be captured and is inclusive of every patient treated.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients treated at the proton center.

Exclusion criteria

Any other than what is supplied in the inclusion criteria

Treatment and study plan

Registry

Other

Registry of cancer patients who receive proton radiation therapy

Primary outcomes

Research registry of cancer patients receiving proton radiation therapy

Time frame: 15 years

This is a clinic based registry of cancer patients' data from participants to be collected over 15 years. The registry will be populated with 3D anatomy and radiation dosimetry from the RayStation treatment planning system used to plan all proton therapy patients. Clinical data will be extracted electronically from the MOSAIQ oncology information system used to manage the radiation therapy treatments. Structured clinical assessments will be routinely captured in the clinical workflow during patient encounters. Patient reported outcomes will be captured with iPad's using the OncoBrowser tools developed in radiotherapy that also interface with MOSAIQ.

Study contacts

Contact information is provided by the study sponsor or research team.

Akila Viswanathan, MD

CONTACT

[email protected]

410-502-1421

Dana Kaplin, MPH

CONTACT

[email protected]

410-614-3950

Sponsors and collaborators

Lead sponsor

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2030
Study completion: 2040
First posted: May 6, 2020
Registry last updated: Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting