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Completed

NCT Number: NCT06848855

Proton Pump Inhibitor Use and Dental Implant Success

The goal of this observational study is to evaluate the effects of proton pump inhibitors (PPIs) on the surrounding bone and the survival of dental implants. The main questions it aims to answer are:

Does PPI use affect the survival rate of dental implants? Does PPI use influence crestal bone loss and fractal dimension (FD) of the surrounding bone?

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Key information

Conditions

Implant Survival Rate Implant Survival and Success

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Kocaeli University

Kocaeli, 41040, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being over 18 years old,
  • Having a history of PPI use for more than six months,
  • Having at least one bone-level and axially placed dental implant in the maxilla or mandible,
  • Having a minimum of one year elapsed since the prosthetic restoration following dental implant placement,
  • Having undergone routine clinical follow-ups and radiological evaluations with periapical radiographs taken using the parallel cone technique after dental implant placement.

Exclusion criteria

  • Individuals with a history of PPI use for less than six months,
  • Individuals with periapical radiographs of low image quality or with artifacts,
  • Individuals for whom the regions selected for fractal analysis on periapical radiographs are not appropriately sized,
  • Individuals who have not undergone routine clinical and radiographic follow-ups.

Treatment and study plan

Primary outcomes

  1. Fractal Dimension Value

    Time frame: Fractal analysis values were calculated on radiographs within 1 month after the data collection of the patients.

Sponsors and collaborators

Lead sponsor

Berkay Tokuç

Other

Registry information

Official study title

Evaluation of the Relationship Between Proton Pump Inhibitor Use and Dental Implant Success: a Retrospective Study

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Feb 27, 2025
Registry last updated
Feb 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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