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OpenTrials
Completed

NCT Number: NCT06305156

Protocol Optimization in CT for the Quantification of BMD

Bone mineral density is an important measurement to detect osteoporosis.

The goal of this clinical trial is to compare bone mineral density measurements in CT examinations and DXA scans. The main question it aims to answer is:

* How good is the measurement of bone mineral density in the new photon-counting CT in comparison to DXA * How can we optimize the CT scan for bone mineral density

Participants will undergo:

* Clinically indicated CT scan on day of inclusion * Study related DXA scan on a separate appointment

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Key information

Conditions

Osteoporosis, Osteopenia Bone Diseases Bone Diseases, Metabolic Bone Loss Metabolic Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases Osteoporosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Diagnostic and Interventional Radiology, University Hospital Zurich

Zurich, Canton of Zurich, 8091, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Informed Consent signed by the subject
  • Referral to a regular clinically indicated CT examination covering the lumbar area (e.g., Abdomen, Thorax + Abdomen, Neck + Thorax +Abdomen)
  • Informed written and oral consent (interpreter present in case of foreign language patients)
  • No contraindication to the clinically indicated CT examination

Exclusion criteria

  • Patients < 18 years
  • Pregnant women
  • Vulnerable subjects
  • Contraindications to the clinically indicated CT scan
  • Multiple Myeloma
  • Diffuse bone metastasis
  • Fixateur interne in the lumbar spine
  • Kyphoplasty in the lumbar spine
  • Enterally administrated contrast agent
  • Obtaining informed consent is not possible
  • Withdrawal of consent orally or in writing
  • Inability to follow the procedures of the investigation, e.g., due to language problems, psychological disorders, dementia, etc. of the subject
  • Immobility (patients confined to a wheelchair or to bed)

Treatment and study plan

Bone Mineral Density quantification

Diagnostic Test

In the first visit, participants receive clinically indicated CT scan, where bone mineral density will be derived.

In a second, study related visit, participants will receive a DXA scan for bone mineral quantifications.

Primary outcomes

  1. Bone mineral density CT

    Time frame: Immediately after CT scan of the participant.

    Bone mineral density derived from CT Scan

  2. Bone mineral density Dual-energy x-ray absorptiometry (DXA)

    Time frame: Immediately after DXA scan of the participant.

    Bone mineral density derived from DXA Scan

Secondary outcomes

  1. Correlation between age and bone mineral density

    Time frame: 1 year

    Correlation analysis by means of linear regression and pearson correlation between age (in years) and bone mineral density

  2. Correlation between sex and bone mineral density

    Time frame: 1 year

    Correlation analysis by means of linear regression and pearson correlation between sex (male/female) and bone mineral density

  3. Correlation between height and bone mineral density

    Time frame: 1 year

    Correlation analysis by means of linear regression and pearson correlation between height (in cm) and bone mineral density

  4. Correlation between weight and bone mineral density

    Time frame: 1 year

    Correlation analysis by means of linear regression and pearson correlation between weight and bone mineral density

  5. Correlation between body mass index (BMI) and bone mineral density

    Time frame: 1 year

    Correlation analysis by means of linear regression and pearson correlation between body mass index (BMI, in kg/m^2) and bone mineral density

Sponsors and collaborators

Lead sponsor

Hatem Alkadhi

Other

Registry information

Official study title

Protocol-optimization in Computed Tomography for the Quantification of Bone Mineral Density (BMD)

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 12, 2024
Registry last updated
Jan 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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