Protocol for Evaluation of Quarter-Time Cardiac Imaging: 5-Minutes Rest and 3-Minutes Stress Wide Beam Reconstruction (WBR) Versus Full-Time Filtered Back Projection (FBP)

A new, innovative software image processing method, wide beam reconstruction (WBR), utilizes resolution recovery and incorporates Poisson noise-reduction into the reconstruction process of NM images. This method facilitates the reconstruction of low count density myocardial perfusion SPECT images. Preliminary research indicates that SPECT acquisition time consequently can be reduced by 60% (less than 5 minutes) for rest and by 75% (just over 3 minutes) for stress, while tomographic image quality is maintained, or even improved. Such a decrease in image acquisition time decreases patient discomfort during the tomographic acquisition, decreases the opportunity for patient motion, and improves laboratory efficiency.

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Key information

Conditions

Cardiac Diseases Cardiovascular Diseases Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Standard full-time SPECT will be processed using FBP and compared to 3-minute stress and 5-minute rest scans processed with WBR. The following scan parameters will be evaluated: image quality; perfusion defect extent, severity, and reversibility; transient ischemic dilatation; left ventricular end-diastolic volume; left ventricular end-systolic volume; left ventricular ejection fraction; and regional wall motion and wall thickening abnormalities. These parameters will be assessed visually by experienced Nuclear physicians (at least 2 blinded readers) and quantitatively using several different commercially available software programs.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient is clinically stable
Patient is able to tolerate additional 8 minutes of scanning
Patient is willing to undergo additional 8 minutes of scanning

Exclusion criteria

Unstable patient
Non-consenting patient

Treatment and study plan

quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac

Device

Comparison of the diagnostic quality of quarter-time WBR stress with stress studies generated via FBP and half-time WBR

Other names: WBR, wide-beam reconstruction, Xpress3.Cardiac

quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac

Device

Comparison of the diagnostic quality of 6 SPS quarter-time rest acquisitions with FBP and half-time WBR rest studies; simulated 8 SPS and 10 SPS quarter-time rest acquisitions are also compared to FBP and half-time WBR rest studies.

Other names: WBR, wide-beam reconstruction, Xpress3.Cardiac

Primary outcomes

Image quality of quarter-time WBR images is equivalent/superior to full-time FBP

Time frame: March 2008

Secondary outcomes

Image quality of quarter-time WBR is equivalent/superior to half-time WBR

Time frame: March 2008

Sponsors and collaborators

Lead sponsor

St. Luke's-Roosevelt Hospital Center

Other

Registry information

Official study title

Quarter-Time Myocardial Perfusion SPECT

Important dates

Study start: 2007
Primary completion: 2007
Study completion: 2008
First posted: Apr 18, 2008
Registry last updated: Aug 26, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed