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NCT Number: NCT06787807

Proteomic Analysis of Patients Undergoing Bariatric Surgery

The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery. Therefore, this research aims to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-operative status. The objective of this research is to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-surgery status.

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Key information

Conditions

Obesity Adnexal Diseases Biliary Tract Diseases Biliary Tract Neoplasms Blood Protein Disorders Body Weight Breast Cancer Breast Diseases Breast Neoplasms Cardiovascular Diseases Central Nervous System Neoplasms Colon Cancer Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Endometrial Cancer Endometrial Neoplasms Esophageal Cancer Esophageal Diseases Esophageal Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gallbladder Cancer Gallbladder Diseases Gallbladder Neoplasms Gastric Cancer Gastrointestinal Diseases Gastrointestinal Neoplasms Genital Diseases Genital Diseases, Female Genital Diseases, Male Genital Neoplasms, Female Genital Neoplasms, Male Gonadal Disorders Head and Neck Neoplasms Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Immune System Diseases Immunoproliferative Disorders Intestinal Diseases Intestinal Neoplasms Kidney Cancer Kidney Diseases Kidney Neoplasms Liver Cancer Liver Diseases Liver Neoplasms Lymphoproliferative Disorders Male Urogenital Diseases Meningeal Neoplasms Meningioma Multiple Myeloma Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Nerve Tissue Neoplasms, Plasma Cell Neoplasms, Vascular Tissue Nervous System Diseases Nervous System Neoplasms Nutrition Disorders Nutritional and Metabolic Diseases Ovarian Ovarian Cancer Ovarian Diseases Ovarian Neoplasms Overnutrition Overweight Pancreatic Cancer Pancreatic Diseases Pancreatic Neoplasms Paraproteinemias Pathological Conditions, Signs and Symptoms Potmenopausal Breast Cancer Prostate Cancer Prostatic Diseases Prostatic Neoplasms Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases Stomach Diseases Stomach Neoplasms Thyroid Cancer Thyroid Diseases Thyroid Neoplasms Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms Uterine Diseases Uterine Neoplasms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital das clínicas da UFPE

Recife, Pernambuco, 50670901, Brazil

About this study

The objective of this study is to analyze the Proteomics of obese patients in the preoperative context of bariatric surgery to evaluate which are the up-regulated proteins - potentially related to oncogenic metabolic pathways - and also the down-regulated proteins in the context of obesity - potentially protective in the context of cancer. As well as, evaluate the variation of these proteins, as well as the metabolic pathways with which they are associated, after weight loss promoted by bariatric surgery, in the period of 01 year after this intervention.

The proteomic study will be carried out based on the formation of pools organized based on the patients' pre- and postoperative similarities. Proteomic analyzes will be carried out on a high-performance liquid chromatography system (nanoUPLC) model Acquity Mclass, Waters. Coupled to a Quadrupole Mass Spectrometer-Time of Flight (QToF) Model Sunapt Xs, Waters. Finally, the raw data (raw mass spectra) will be analyzed by the PROGENESIS QI software (Waters) to identify the proteins.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients over 18 years of age with a BMI above 35 kg/m² associated with comorbidity or BMI above 40 kg/m² without comorbidities,

Exclusion criteria

Patients with a previous history of cancer;
Underage patients
Patients with other diseases predisposing to the development of cancer: cirrhosis, ulcerative colitis, Barrett's esophagus, etc.
Patients who have previously undergone bariatric surgery;

Treatment and study plan

bariatric surgery

Procedure

sleeve gastrectomy

Other names: sleeve gastrectomy

Primary outcomes

Number of patients with reduced initially upregulated oncogenic proteins

Time frame: 1 year after bariatric surgery

reduction of proteins potentially involved in oncogenic metabolic pathways, initially upregulated in the context of obesity

Study contacts

Contact information is provided by the study sponsor or research team.

Júlia M Lins, medicine student

CONTACT

[email protected]

5581996906749

Luiz Henrique A Bandeira, Medicine student

CONTACT

[email protected]

5581987082731

Sponsors and collaborators

Lead sponsor

Universidade Federal de Pernambuco

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Jan 22, 2025
Registry last updated: Jan 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed