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Completed

NCT Number: NCT00834236

Proteiomic Fingerprints of Gastric Juice

No accurate, inexpensive and non-invasive test for gastric cancer screening is currently available. The investigators' recent study identified a1-antitrypsin and other proteins as potential biomarkers of gastric cancer in gastric juice. The aim of this study was to develop a novel non-invasive modality for detecting gastric cancer by measurement of biomarkers in gastric juice.

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Key information

Conditions

Gastric Cancer Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Neoplasms Neoplasms by Site Stomach Diseases Stomach Neoplasms

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kaohsiung Veterans General Hospital, Kaohsiung City, Kaohsiung, Taiwan

Loading trial locations.

About this study

Patients and methods: The study consisted of two parts: (1) investigating the differences in gastric juice biomarker concentrations between gastric cancer patients and controls, and (2) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for biomarker concentration.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy subjects and gastric cancer patients documented by endoscopy.

Exclusion criteria

  • the use of proton pump inhibitors or histamine-2 receptor antagonists within 4 weeks prior to the study
  • coexistence of two kinds of gastroduodenal lesions
  • coexistence of severe systemic diseases

Treatment and study plan

normal subject

Other

biomarker in gastric juice, i.e., alpha 1-antitrypsin, CEA

Other names: biomarker in gastric juice

gastric cancer

Other

biomarker in gastric juice, e.g., alpha 1-antitrypsin

Other names: biomarker in gastric juice

Primary outcomes

  1. Number of Participants With Accurate Diagnosis for Gastric Cancer

    Time frame: 2 months

    Normal subject group: number of the subjects with normal alpha 1-antitrypsin level in gastric juice Gastric cancer group: number of the subjects with elevated alpha 1-antitrypsin level in gastric juice

Sponsors and collaborators

Lead sponsor

Kaohsiung Veterans General Hospital.

Other

Collaborators

  • National Science and Technology Council, Taiwan

Registry information

Official study title

Diagnosis of Gastroduodenal Diseases by Proteiomic Fingerprints of Gastric Juice

Important dates

Study start
2008
Primary completion
2011
Study completion
2011
First posted
Feb 3, 2009
Registry last updated
Dec 7, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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