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Completed

NCT Number: NCT03393650

Protein Supplementation and Mixed Power Training on Muscle Function and Functional Capacities in Elderly Men

Investigate the effect of 12 weeks mixed power training (power and functional exercises) combined with a protein supplementation (30g/d) or not (placebo) on physiological characteristics of muscle and functional capacities in elderly men.

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Key information

Conditions

Dynapenia Aging Behavior Motor Activity Physical Impairment

Age range

60 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

Life habits are know to be able to prevent the loss of functional capacities and muscle function during aging process. More specifically, protein intake is important to maintain muscle function in older adults. Another non pharmacological intervention and well recognized for its efficacy, it's exercise training.

Recently, it has been observed than muscle quality is more important to maintain physical autonomy than muscle mass per se. In addition, muscle quality is more related to functional capacities than muscle mass.

Due to this recent finding, it has been proposed that muscle power training would be the best exercise intervention to prevent the loss of mobility.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elderly men
  • 60 years and older
  • Sedentary men
  • Not obese (BMI <30 kg/m2)
  • Living in free-living community

Exclusion criteria

  • Not able to follow an exercise program (doctor authorization: XAAP)
  • Having Lactose intolerance
  • Having Pace marker
  • Having Metabolism disorder
  • No weight stable since the last 6 months
  • No stable medication (same dose and type since at least 6 months)

Treatment and study plan

Exercise + Placebo group

Other

1/2 of the subject will follow a mixed power training: 4 power exercises + 6 functional exercises combined to a placebo

Exercise + Protein group

Other

1/2 of the subject will receive 30 g/ d of protein (leucine+ vitD; divided in three equal doses: morning, afternoon and evening) + will follow a mixed power training: 4 power exercises + 6 functional exercises.

Primary outcomes

  1. Change in walking speed

    Time frame: Change from Baseline walking speed at 12 weeks measure in all subjects

    evaluate using the 4m- normal walking speed (m/sec)

Secondary outcomes

  1. Change in lower limb muscle quality

    Time frame: Change from Baseline lower limb muscle quality at 12 weeks measure in all subjects

    Knee extension muscle strength (isometric (N)/ lower limb muscle mass (kg))

Other outcomes

  1. Change in mitochondrial activity

    Time frame: Change from Baseline mitochondrial activity at 12 weeks measure in half of the subjects

    citrate synthase activity (unit: percent)

Sponsors and collaborators

Lead sponsor

Université du Québec a Montréal

Other

Registry information

Official study title

Effect of Protein Supplementation Combined With Mixed Power Training on Muscle Function, Composition, Phenotype and Functional Capacities Compared to Mixed Power Training Alone in Elderly Men

Acronym: PROMU

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Jan 8, 2018
Registry last updated
Jan 8, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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