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OpenTrials
Enrolling by Invitation

NCT Number: NCT06735573

Protein, Sarcopenic Obesity, and COPD

Both sarcopenic obesity and chronic obstructive pulmonary diseases (COPD) are common conditions that mainly affect middle-aged and older adults. Previous research has shown that increased dietary intake of total and plant-based protein is associated with a lower risk of sarcopenic obesity, using data from the EPIC Norfolk study. Furthermore, a systematic review and meta-analysis showed that having sarcopenic obesity was associated with significantly impaired lung function outcomes. Other research has shown that increased intake of dietary protein leads to a better treatment outcome for respiratory diseases. The aim of this pilot observational study is to investigate, in more detail, the relationship between the quantity and source of dietary protein intake, the prevalence of sarcopenic obesity, and lung function, in a small cohort of older female participants with COPD. The study will also consider the role of inflammation in relation to sarcopenic obesity and lung function outcomes. This study will help to improve the understanding of the relationship between sarcopenic obesity and lung function outcomes, and how dietary protein intake and inflammation can affect this relationship and each of the outcomes.

Enrolling by Invitation

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Key information

Age range

55 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Baukje de Roos

Aberdeen, Scotland, AB25 2ZD, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women.
  • Clinically diagnosed with COPD.
  • Aged 55 years or older.

Exclusion criteria

  • Male.
  • Women who are 54 years or younger.
  • Those who have dementia.
  • Unable to read or write in English.
  • Unable to attend the Human Intervention Studies Unit.
  • Those within one year life expectancy.
  • Those who have cancer.

Treatment and study plan

the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes

Other

Primary Objective The primary objective is to measure the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes, in older female participants with clinically diagnosed COPD.

Secondary Objectives The secondary objective is to investigate whether the level of inflammation (plasma CRP) is associated with the intake of total, plant-based and animal-based protein, with the prevalence of sarcopenic obesity, and with lung function outcomes.

Other names: the level of inflammation (plasma CRP)

Primary outcomes

  1. Association between dietary protein and the prevalence of sarcopenic obesity

    Time frame: through study completion, an average of 1 year

    Association between dietary intake of total, plant-based and animal-based protein and the prevalence of sarcopenic obesity.

Secondary outcomes

  1. Association between dietary protein and lung functions outcomes

    Time frame: through study completion, an average of 1 year

    Association between dietary intake of total, plant-based and animal-based protein and lung functions outcomes (Forced Vital Capacity (FVC), Forced Expiratory Volume in The First Second(FEV1), and The Ratio of Forced Expiratory Volume in The First Second to Forced Vital Capacity (FEV1/FVC ratio)).

Sponsors and collaborators

Lead sponsor

University of Aberdeen

Other

Registry information

Official study title

Observational Study to Explore the Relationship Between Dietary Protein Intake and the Prevalence of Sarcopenic Obesity in Adult Female With Chronic Obstructive Pulmonary Disease (COPD): A Pilot Study

Acronym: PROSO-COPD

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Dec 16, 2024
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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