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Completed

NCT Number: NCT02859181

Protein Requirements for Active Adolescent Males (IAAO-AM)

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.

The purpose of this study is to measure the protein requirement in adolescent, males using the IAAO technique in the presence of a variable intensity exercise stimulus.

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Key information

Conditions

Healthy

Age range

10 year–15 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Goldring Centre for High Performance Sport

Toronto, Ontario, M5S2C9, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(Adolescents):

  • Healthy, active adolescent who regularly participates in moderate to vigorous physical activity 5 times a week for a minimum of 1 hour.
  • Being -0.5 to +1.0 years from peak height velocity, determined by the ratio of standing to sitting height, with the maximal age for adolescents being 16 years.
  • Obtaining a minimum level of 8.3 on the Beep Test

Exclusion criteria

(All Subjects):

  • Inability to meet health and physical activity guidelines according to the Physical activity readiness questionnaire (PAR-Q+) and Physical Activity Questionnaire,
  • an inability to adhere to any of the protocol guidelines (i.e. caffeine consumption)
  • a biological age falling outside of the aforementioned ranges

Treatment and study plan

Amino acid intake

Dietary Supplement

Amino acid intakes will be varied at 0.2-2.67 g/kg/d

Primary outcomes

  1. 13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h)

    Time frame: 4 hours per study day

    Each trial day will assess a different protein intake with 13CO2 excretion defining the level of protein adequacy. Each trial day will be separated by ~1wk washout with all trial being completed in approximately 3 months.

Secondary outcomes

  1. [13C]Phenylalanine Oxidation (µmol/kg/h)

    Time frame: 4 hours per study day

    Each trial day will assess a different protein intake with 13CO2 excretion defining the level phenylalanine oxidation being used as a secondary marker of protein adequacy. Each trial day will be separated by ~1wk washout with all trial being completed in approximately 3 months.

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Collaborators

  • Ajinomoto Co., Inc.

Registry information

Official study title

Evaluation of Protein Requirements in Active Adolescent Males

Important dates

Study start
2016
Primary completion
2017
Study completion
2018
First posted
Aug 8, 2016
Registry last updated
Mar 29, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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