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OpenTrials
Completed

NCT Number: NCT02315391

Protein Nutrition for Muscle Hypertrophy in Older Adults

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.

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Key information

Conditions

Healthy Elderly Muscle Anabolically Resistant Elderly Muscle

Age range

65 year–80 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Must habitually complete a minimum of 5000 steps per day
  • Having obtained informed consent
  • Non-obese
  • Non-smoker

Exclusion criteria

  • Aged >80 years
  • Inability to comply with study procedures
  • Currently participating or having participated in another infusion trial during last 12 months
  • Any acute or chronic llness
  • History of neuromuscular problems
  • Medications known to affect protein metabolism
  • Individuals who complete fewer than 5000 steps per day
  • Individuals who have metal implants

Treatment and study plan

Isolated Whey Protein

Dietary Supplement

isolated whey protein

micellar whey protein

Dietary Supplement

micellar whey protein

Glycine

Dietary Supplement

glycine

Citrulline

Dietary Supplement

citrulline

Primary outcomes

  1. Change in myofibrillar fractional synthetic rate (FSR)

    Time frame: one day and 2 weeks

Secondary outcomes

  1. change in non-myofibrillar fractional synthetic rate (FSR)

    Time frame: baseline and one day of feeding

  2. Capillary dilatation and blood flow

    Time frame: 2 weeks

    Determine if inactivity reduces the feeding-induced increase in capillary dilation and nutrient delivery and whether citrulline rescues this in "resistant" muscle or augments it in the "healthy" muscle as measured by Definity infusion and contrast enhanced ultrasound (CEUS)

Sponsors and collaborators

Lead sponsor

Société des Produits Nestlé (SPN)

Industry

Registry information

Official study title

Efficacy of Isolated Whey and Micellar Whey Protein (+/- Citrulline) to Stimulate Protein Synthesis in 'Healthy' and 'Anabolically Resistant' Elderly Muscle

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Dec 11, 2014
Registry last updated
Dec 18, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.