Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors

• The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were used for prognostic analysis.

(1) The diagnosis and treatment information of cervical neuroendocrine carcinoma in multiple hospitals was collected, including clinical and medical data such as age, preoperative HPV genotyping, preoperative biopsy pathological results, postoperative histopathological results, FIGO staging, prognosis and survival information, and follow-up of patients.

• Protein and other omics analysis was performed on paraffin tissues of 100 cases of cervical neuroendocrine tumors Paraffin samples collected from 100 cases of cervical neuroendocrine tumors were identified, processed and segmtioned, and protein concentration and proteome were determined to establish the molecular characteristics and prognostic targets of cervical neuroendocrine tumors.

Inclusion criteria

• Patients diagnosed with cervical neuroendocrine carcinoma by histopathology
• Clinical data were complete

Exclusion criteria

• Patients who are not being treated in our hospital
• Patients with lack of follow-up data, unable to obtain survival information
• Patients call to refuse to participate in this project
• The quality of paraffin specimens can not meet the requirements of proteome concentration determination