Skip to main content
OpenTrials
Completed

NCT Number: NCT05584358

Protein Extrusion and Postprandial Amino Acid Handling

The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders. However, the protein that we consume on a daily basis has typically undergone various processing methods, and evidence suggests these can change the way our bodies metabolise the protein. 'Extrusion' is a common processing method that uses high pressure to produce protein containing cereals and meat replacement foods. There is currently no research looking at how extrusion affects the way a protein source is digested and absorbed in humans. This study will compare the availability of ingested protein in the blood in the hours following consumption of an extruded versus a non-extruded source.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sport & Health Sciences University of Exeter, Exeter, Devon, United Kingdom

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18 and 30.
  • Metabolically healthy

Exclusion criteria

  • Any metabolic impairments
  • cardio/pulmonary diseases.
  • Chronic use of the over the counter medicine
  • A personal or family history of epilepsy, seizures or schizophrenia.
  • Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Treatment and study plan

Dry protein blend ingestion

Dietary Supplement

Ingestion of protein blend powders mixed in water

Extruded protein blend ingestion

Dietary Supplement

Ingestion of protein blend powders mixed in water

Primary outcomes

  1. Plasma amino acid concentrations

    Time frame: 5 hours

    The rate of appearance of amino acids ingested in the drink

Secondary outcomes

  1. Blood glucose

    Time frame: 5 hours

    The concentrations of glucose in the blood

  2. Serum insulin

    Time frame: 5 hours

    The concentration of insulin in the blood

  3. Resting metabolic rate

    Time frame: 5 hours

    The amount of energy used to digest the protein

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • Quorn

Registry information

Official study title

The Impact of the Extrusion Process During Dietary Protein Production on in Vivo Postprandial Amino Acid Availability

Acronym: BABE

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Oct 18, 2022
Registry last updated
Jan 11, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.