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OpenTrials
Completed

NCT Number: NCT00899340

Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx.

PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

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Key information

Conditions

Head and Neck Cancer Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Squamous Cell Carcinoma of Head and Neck

Sex eligibility

All sexes

Study type

Observational

About this study

OBJECTIVES:

  • To investigate if some of the differences in gene expression are also reflected at the protein level.
  • To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
  • To identify targets for therapy.

OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of squamous cell carcinoma of the oropharynx
  • Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives

Exclusion criteria

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified

Treatment and study plan

gene expression analysis

Genetic

profiles of HPV(+) and (-) HNSCCs

microarray analysis

Genetic

microarray analysis

Other names: SAM - significance Analysis of microarrays

protein expression analysis

Genetic

protein expression analysis

immunohistochemistry staining method

Other

immunohistochemistry staining method

laboratory biomarker analysis

Other

laboratory biomarker analysis

Primary outcomes

  1. Development of biomarkers for early detection or recurrence surveillance

    Time frame: after 7 months of tissue collection

  2. Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx

    Time frame: after 7months of tissue collection

Sponsors and collaborators

Lead sponsor

Vanderbilt-Ingram Cancer Center

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
May 12, 2009
Registry last updated
Apr 2, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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