Low protein diet
OtherPatients will be managed with a restricted protein intake (controlled protein diets with a mean target at 0.6 g / kg / day of protein, according to a choice of dietary approaches, adapted to the situation of each patient).
NCT Number: NCT03979534
Nephrology care continues to progress and recommendations are now focused on delaying as much as possible the need for renal replacement therapy ("intent-to-defer"strategy). Protein restriction is a valuable tool for stabilizing chronic kidney disease (CKD) and retarding the need for renal replacement therapy, but the best diet to be prescribed is still matter of discussion. This study is aimed at identifying implementation strategies for nutritional management of advanced CKD.
Interested in participating?
Request Info18 year and older
All sexes
Interventional
Not applicable
Pôle Santé Sarthe et Loir, La Flèche, France
The recent paradigm on dialysis start suggests that an intention to defer policy should be preferred to beginning dialysis early ("the earliest the best" strategy). This strategy is further supported by the consideration that patient profiles are changing with the increasing proportion of older and higher comorbidity patients. In high comorbidity patients, survival is not necessarily improved by dialysis.
Nutritional care, adapted to each patient's needs and preferences, could in part answer these demands. Indeed, renal function has a strict correlation with dietary patterns. Low protein diets may have two favourable effects: 1) slowing down kidney function decline and 2) delaying the need of replacement therapy (metabolic stabilizing). In dialysis, the nutritional state is the most important survival indicator, and nutritional follow-up should allow starting dialysis in a good nutritional status.
The study proposed here is an implementation study with a principal aim to improve the use of low protein diets in the clinical setting, by offering a multiple choice approach and by adapting the diets to the patients' needs.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Patients will be managed with a restricted protein intake (controlled protein diets with a mean target at 0.6 g / kg / day of protein, according to a choice of dietary approaches, adapted to the situation of each patient).
Time frame: 4 years
Percentage of patients who drop-out of the multiple choice diet program
Time frame: 4 years
The "kidney survival" from the beginning of the diet to the start of renal replacement therapy
Time frame: 4 years
The patient survival compared to reference data (from the Réseau Epidemiologie, Information, Néphrologie) and international registers.
Time frame: 4 years
Cost of the treatment, including diet, renal replacement therapy and pharmacological interventions.
Time frame: 4 years
Percentage of patients without contraindications enrolled on the pre-emptive kidney transplant list.
Time frame: 4 years
Percentage of patients without contraindications who started a home dialysis treatment
Time frame: 4 years
Percentage of patients without contraindications who started dialysis with an incremental schedule.
Contact information is provided by the study sponsor or research team.
Centre Hospitalier le Mans
Other
Acronym: ProReRePro
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