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OpenTrials
Completed

NCT Number: NCT03896178

Prostate Cancer in Firemen: Early Diagnosis Because of Increased Diagnostic Pressure?

Firefighters, police, military personnel and pilots are all shown to have a higher incidence of prostate cancer than the general population. A possible explanation for this is that these four groups of employees need regular mandatory health-checkups. If these checkups increase the chances of having a PSA or DRE performed one could expect the workers in question to have a higher probability than the general population of being diagnosed with prostate cancer. If this is the case the four groups should have cancers that are lower grade and have better survival. The investigators wish to examine this by comparing the four groups with a control group made up of all other workers with regards to prognostic factors at the time of diagnosis and survival rates. This will be done by extracting data from the Cancer Registry of Norway, coupled with employment data from Statistics Norway. This study is also a part of a project on cancer in firefighters. If the prostate cancers in firefighters differ significantly from the other three specified groups, this could point to an exposure specific for firefighters, e.g. fire smoke, as an etiologic factor.

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Key information

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

Primary location

Cancer Registry of Norway

Oslo, 0304, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All cases of prostate cancer as registered by the Cancer Registry of Norway

Exclusion criteria

  • None

Treatment and study plan

none, observational study

Other

None, observational study

Primary outcomes

  1. Cause-specific mortality rate for prostate cancer

    Time frame: From January 1st 1960 until December 31st 2018

Secondary outcomes

  1. TNM staging

    Time frame: January 1st 1960 until December 31st 2018

  2. Gleason score

    Time frame: January 1st 1960 until December 31st 2018

    Score based on microscopic appearance of prostate cancer tissue. Sum of two scores, each ranging from 1-5 (only whole numbers), meaning the final score ranges from 2-10. A higher score is associated with a more aggressive/less differentiated tumor. It is normal to group scores 2-6 together in >7. It is also normal to differentiate between 7 (4+3) (worse), and 7 (3+4) (better).

  3. PSA at time of diagnosis

    Time frame: January 1st 1960 until December 31st 2018

  4. Functional status at time of diagnosis (WHO classification)

    Time frame: January 1st 1960 until December 31st 2018

Sponsors and collaborators

Lead sponsor

Oslo University Hospital

Other

Collaborators

  • Extrastiftelsen
  • Fagforbundet
  • Gjensidige Foundation
  • National Institute for Occupational Safety and Health (NIOSH/CDC)
  • Norwegian Cancer Society
  • Norwegian Confederation of Trade Unions
  • Norwegian Firefighters Fight Cancer
  • Norwegian Institute of Public Health
  • Norwegian Labour Inspection Authority

Registry information

Official study title

Early Detection of Prostate Cancer in Firefighters - a Register-based Study of Prognostic Factors and Survival

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Mar 29, 2019
Registry last updated
Mar 1, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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