Prostasin Levels in Preeclamptic Women

This study will aim to compare maternal serum prostasin levels between women diagnosed with preeclampsia and healthy normotensive pregnant controls. Participants will be divided into two main groups: those with preeclampsia and those with uncomplicated pregnancies. The preeclampsia group will further be subdivided based on the severity of the condition. Maternal serum samples will be collected from all participants, and prostasin levels will be measured using ELISA. Statistical analyses will be performed to evaluate whether prostasin levels are significantly elevated in the preeclampsia group, particularly in those with severe features, and to assess its potential as a biomarker for the condition.

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Key information

Conditions

Pre-eclampsia Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pregnancy Complications Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Cam and Sakura City Hospital

Istanbul, 34480, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of Preeclampsia: Defined by new-onset hypertension (systolic Blood Pressure ≥140 mmHg and/or diastolic Blood Pressure ≥90 mmHg) after 20 weeks of gestation, with or without proteinuria.
Control Group: Healthy pregnancies without preeclampsia or other significant maternal or fetal complications.

Exclusion criteria

Multiple Pregnancies
Pregestational Diabetes
Chronic Hypertension
Systemic Diseases (Chronic kidney disease, autoimmune diseases)
Fetal Anomalies
Premature Rupture of Membranes.

Treatment and study plan

Primary outcomes

Maternal Serum Prostasin Levels

Time frame: Up to 8 weeks (Patients will be followed from inclusion in the study until the end of their pregnancy.

To compare Prostasin Levels between the pre-eclampsia and the control group.

Sponsors and collaborators

Lead sponsor

Başakşehir Çam & Sakura City Hospital

Other Gov

Registry information

Official study title

Prostasin Levels in Preeclampsia: A Comparative Study With Healthy Pregnancies

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Oct 2, 2024
Registry last updated: Oct 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed