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OpenTrials
Active, Not Recruiting

NCT Number: NCT05518396

Prospective Validation of the CoDE-HF Algorithm for the Diagnosis of Acute Heart Failure

Acute heart failure is a life-threatening condition where the heart is suddenly unable to pump blood around the body. It can be challenging to diagnose because the symptoms often mimic other conditions. Previous studies have showed that delays in making the correct diagnosis result in worse outcomes. We therefore developed a decision-support tool called CoDE-HF that uses a computer algorithm to combine levels of a blood test called NT-proBNP with patient factors to calculate the probability of acute heart failure for an individual.

In this project, we wish to evaluate the performance of CoDE-HF in approximately 2,000 patients attending the Emergency Department with suspected acute heart failure. We will store surplus material from their blood tests to measure NT-proBNP and link information from their electronic health records with other routinely collected medical information in regional and national databases in order to evaluate this algorithm.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Acute Heart Failure Diagnosis Disease Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre for Cardiovascular Science, University of Edinburgh

Edinburgh, EH16 4SB, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients presenting to the Emergency Department with acute breathlessness

Treatment and study plan

CoDE-HF decision support tool

Diagnostic Test

We will assess the diagnostic performance of the CoDE-HF decision support tool

Primary outcomes

  1. Adjudicated diagnosis of acute heart failure

    Time frame: At index presentation

Secondary outcomes

  1. Subsequent hospitalisation with heart failure

    Time frame: 3 months

  2. All-cause death

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • NHS Lothian

Registry information

Acronym: ProVa CoDE-HF

Important dates

Study start
2021
Primary completion
2024
Study completion
2028
First posted
Aug 26, 2022
Registry last updated
Feb 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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