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NCT Number: NCT03225586

Prospective Urban Rural Epidemiology Study

To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g. death, non-communicable disease development) across a range of socioeconomic and health resource settings. Additional components of this study will examine genetic factors for non-communicable diseases. This will be examined both through a cross sectional component, and prospectively (cohort component).

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Key information

Conditions

Cardiovascular Diseases Behavior Cancer Communicable Disease Communicable Diseases Disease Attributes Environmental Exposure Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Health Behavior Infections Injuries Kidney Diseases Lung Diseases Male Urogenital Diseases Neoplasms Noncommunicable Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Disease Respiratory Tract Diseases Risk Factor, Cardiovascular Urogenital Diseases Urologic Diseases Wounds and Injuries

Age range

35 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Estudios Clinicos Latinoamerica ECLA, Rosario, Santa Fe Province, Argentina

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About this study

  • To examine the relationship between societal influences and prevalence of risk factors and chronic noncommunicable diseases. Societal determinants are measured by an index of measures from each of the 4 domains of interest: built environment, food and nutrition policy, psychosocial/socioeconomic factors, and tobacco.
  • To examine the relationship between societal determinants and incidence of chronic noncommunicable disease events (e.g. cardiovascular disease, cancer) and on changes in rates of selected risk factors (e.g. smoking)
  • To examine the relationship between health related behaviors (e.g. diet, physical activity, smoking, alcohol) and health outcomes (e.g. death, non-communicable diseases)
  • The quality of health systems across a diverse range of health resource settings, and how this impacts health outcomes
  • Genetic factors for non-communicable diseases

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • consenting adults between 35-70 years of age

Exclusion criteria

  • none

Treatment and study plan

Primary outcomes

  1. incident cardiovascular disease

    Time frame: mean follow up of 10 years

    cardiovascular death, stroke, myocardial infarction, heart failure

Secondary outcomes

  1. incident cancer

    Time frame: mean follow up of 10 years

    total and cause specific cancers

  2. Incident COPD

    Time frame: mean follow up of 10 years

    development of COPD

  3. Incident Asthma

    Time frame: mean follow up of 10 years

    development of asthma

  4. Pneumonia

    Time frame: mean follow up of 10 years

    hospitalization for pneumonia

  5. Respiratory outcomes

    Time frame: mean follow up of 10 years

    change in pulmonary function test

  6. All Cause Hospitalizations

    Time frame: mean follow up of 10 years

    All cause hospitalizations

  7. Kidney disease

    Time frame: mean follow up of 10 years

    end stage renal disease, dialysis, transplant, changes in renal function

  8. All cause and cause specific mortality

    Time frame: mean follow up of 10 years

    death from all causes, and cause specific deaths

  9. incident diabetes

    Time frame: mean follow up of 10 years

    development of diabetes

  10. obesity

    Time frame: mean follow up of 10 years

    development of obesity, change in BMI

  11. hypertension

    Time frame: mean follow up of 10 years

    development of hypertension and changes in blood pressure

  12. incident injuries

    Time frame: mean follow up of 10 years

    assessing fatal and non-fatal injuries due road traffic accidents and falls

Study contacts

Contact information is provided by the study sponsor or research team.

Janette Panhuis, BScN, MBA

CONTACT

[email protected]

905-521-2100 ext. 40386

Sumathy Rangarajan, MSc

CONTACT

[email protected]

905-521-2100 ext. 40464

Sponsors and collaborators

Lead sponsor

Population Health Research Institute

Other

Collaborators

  • Canadian Institutes of Health Research (CIHR)
  • Heart and Stroke Foundation of Ontario

Registry information

Acronym: PURE

Important dates

Study start
2002
Primary completion
2030
Study completion
2030
First posted
Jul 21, 2017
Registry last updated
Jan 31, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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