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Completed

NCT Number: NCT00877552

Prospective Studies of the Pathogenesis of Schizophrenia

The purpose of this study is to use structural and functional magnetic resonance imaging (MRI) to study children at high risk for schizophrenia. It is hypothesized that children at high risk for schizophrenia will have abnormalities of brain development, especially of the cerebral cortex. The study will also describe normal brain development in children from birth to age 6 years

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

Up to 6 year

Sex eligibility

All sexes

Study type

Observational

Primary location

UNC Department of Psychiatry

Chapel Hill, North Carolina, 27599, United States

About this study

We are currently following enrolled children at 4 and 6 years of age. We are obtaining structural MRIs and rsfMRIs. In addition, we are assessing cognitive function and behavior with Stanford-Binet, BRIEF and BASC.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • control, offspring of mother with schizophrenia or bipolar illness; child with MVM

Exclusion criteria

  • major neurological or medical illness

Treatment and study plan

Primary outcomes

  1. magnetic resonance images (structural and functional)

    Time frame: birth, ages 1, 2 , 4 and 6 years

Secondary outcomes

  1. Cognitive development

    Time frame: 0,1,2,4 and 6 years

Sponsors and collaborators

Lead sponsor

University of North Carolina, Chapel Hill

Other

Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  • National Institute of Mental Health (NIMH)

Registry information

Official study title

Prospective Studies of the Pathogenesis of Schizophrenia (Center Title) Early Brain Development in High Risk Children (Project Title) Early Brain Development in One and Two Year Olds (Associated Grant Title)

Important dates

Study start
2002
Primary completion
2019
Study completion
2019
First posted
Apr 8, 2009
Registry last updated
Feb 6, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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