Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke

Inclusion criteria

Clinical inclusion criteria

• Age ≥18 years;
• Presenting with acute ischemic stroke within 24 hours of time from last known well;
• The patient or patient's representative signs a written informed consent form before enrollment.

Neuroimaging inclusion criteria

• Occlusion of internal carotid artery, or the middle cerebral artery M1 or M2 segments confirmed by computed tomography angiography, magnetic resonance angiography, or digital subtraction angiography;
• The baseline ASPECTS is 0 to 2 based on NCCT or diffusion weighted imaging, or cerebral extra-large ischemic core volume ≥85ml (defined as relative cerebral blood flow <30% on CT perfusion or an apparent diffusion coefficient <620×10^-6 mm2/s on MRI).

Exclusion criteria

• CT or MRI evidence of acute intracranial hemorrhage;
• Evidence of mass effect with ventricular effacement, midline shift or herniation on baseline imaging;
• Females who are pregnant, or those of childbearing, potential with positive urine or serum beta Human Chorionic Gonadotropin test;
• Previous bleeding disorders, severe heart, liver or kidney disease, or sepsis;
• Any terminal illness with life expectancy less than 6 months;
• Participation in other clinical treatment trials.