Recruiting

NCT Number: NCT06859944

Prospective Randomized Non-Inferiority Study Comparing Natural Cycle Frozen Embryo Transfer (NC-FET) to a New Type of Endometrial Preparation for FET: Natural Proliferative Phase (NPP-FET)

Frozen embryo replacement cycle :Two methods traditionally used: the spontaneous cycle and the artificial cycle.Now, Emergence of new protocols: NPP-FET or "Natural proliferative phase - frozen embryo transfer" Demonstrate non-inferiority between the NPP-FET and the spontaneous cycle, and superiority in terms of planning.

Recruiting

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Key information

Conditions

Comparison of Pregnancy Rate (HCG+ Level) Obtained After a Replacement Embryonic in Spontaneous Cycle and Following Protocol "NPP". Comparison

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Hopital Erasme

Brussels, 1070, Belgium

Location status: Recruiting

Location contact

Anne Delbaere

CONTACT

About this study

The protocol Natural proliferative phase/Natural Programmed by Progesterone, Patients with regular cycles, candidates for replacement of embryos frozen in a spontaneous cycle. The monitoring of the cycle is carried out by taking blood and follicular ultrasound between the 10th and 13th day of the cycle. Support luteal phase by intravaginal progesterone (utrogestan 200 mg) 1 tablet, 2 times per day, is initiated once the following criteria are met:

Thickness of the endometrium > 7 mm on ultrasound
Ovarian follicle > 14 mm
Estradiol( E2) > 120 pg/mL Embryo transfer is scheduled on the 6th day of progesterone exposure exogenous. A progesterone dosage on the day of transfer will be systematically realized

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Single transfer Blastocyste

Exclusion criteria

PGT (Preimplantation genetic diagnosis)
Testicular Sperm
Donor oocytes

Treatment and study plan

Embryo transfer

Other

Frozen embryo transfer

Primary outcomes

Comparison of the pregnancy rate (Human chorionic gonadotropin hormone) (HCG+ level) obtained after spontaneous embryo replacement and following the "NPP" protocol.

Time frame: Thrugh study completion (9 months)

Study contacts

Contact information is provided by the study sponsor or research team.

Anne Delbaere

CONTACT

[email protected]

+32 2 555 45 70

Sponsors and collaborators

Lead sponsor

Erasme University Hospital