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Active, Not Recruiting

NCT Number: NCT03444259

Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Atrial Fibrillation Aortic Valve Disease Aortic Valve Stenosis Arrhythmias, Cardiac Arterial Occlusive Diseases Arteriosclerosis Cardiac Arrythmias Cardiac Surgery Cardiac Tumor Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Heart Neoplasms Heart Valve Diseases Mitral Valve Disease Myocardial Ischemia Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Thoracic Neoplasms Vascular Diseases Ventricular Outflow Obstruction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Turku University Hospital

Turku, 20520, Finland

About this study

The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any open-heart cardiac surgery
  • Written informed consent
  • All-comers design

Exclusion criteria

  • No informed consent

Treatment and study plan

cardiac surgery

Procedure

Open heart surgery

Primary outcomes

  1. Atrial fibrillation

    Time frame: postoperatively until 5 years follow-up

    Occurrence of atrial fibrillation

Secondary outcomes

  1. Stroke

    Time frame: postoperatively until 5 years follow-up

    Occurrence of stroke

  2. Transient ischemic attack

    Time frame: postoperatively until 5 years follow-up

    Occurrence of Transient ischemic attack

  3. Myocardial infarction

    Time frame: postoperatively until 5 years follow-up

    Occurrence of Myocardial infarction

  4. Target vessel revascularization

    Time frame: postoperatively until 5 years follow-up

    Occurrence of Target vessel revascularization

  5. All-cause Mortality

    Time frame: postoperatively until 5 years follow-up

    All-cause Mortality

  6. Post-pericardiotomy syndrome

    Time frame: postoperatively until 1 years follow-up

    Occurrence of Post-pericardiotomy syndrome

Sponsors and collaborators

Lead sponsor

University of Turku

Other

Collaborators

  • Brigham and Women's Hospital

Registry information

Official study title

Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

Acronym: CAREBANK

Important dates

Study start
2016
Primary completion
2026
Study completion
2029
First posted
Feb 23, 2018
Registry last updated
May 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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