Prospective Investigation of Multiple Sclerosis in the Three Rivers Region

In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

7 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Pittsburgh

Pittsburgh, Pennsylvania, 15260, United States

Location status: Recruiting

Location contact

Zongqi Xia, MD, PhD

CONTACT

412-383-5377

About this study

Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes, Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis, Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric Sensors, Social Network Questionnaire, Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, and the COVID19 Response Surveys.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inclusion criteria for MS patients include:

Age 7 years or older
Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years)
Diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease
For healthy controls:

Age 7 years or older
Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years)
No known personal history of multiple sclerosis or related disorders
No other chronic diseases
Family members, unrelated household controls, or controls from the general population could be eligible

There is no exclusion criteria.

Treatment and study plan

Primary outcomes

Establish a prospective cohort of well-characterized MS patients and controls

Time frame: within 30 years

For this longitudinal prospective observational study, we will establish a prospective cohort of well-characterized MS patients and controls (2:1).
Investigate the predictors of the variations in disease trajectory and treatment response

Time frame: within 30 years

Understanding the factors that influence disease trajectory and treatment response will pave the way to realize precision medicine in delivering individualized MS care.

Study contacts

Contact information is provided by the study sponsor or research team.

Zongqi Xia, MD, PhD

CONTACT

[email protected]

412-383-5377

Sponsors and collaborators

Lead sponsor

University of Pittsburgh

Other

Registry information

Acronym: PROMOTE

Important dates

Study start: 2016
Primary completion: 2047
Study completion: 2047
First posted: Dec 15, 2016
Registry last updated: Dec 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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