Skip to main content
OpenTrials
Completed

NCT Number: NCT01604655

ProspEctive First Evaluation in Chest Pain Trial

The purpose of this study is to determine the best initial test in patients admitted to the hospital complaining of chest pain.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Chest Pain Dyspnea Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Shortness of Breath Signs and Symptoms Signs and Symptoms, Respiratory Suspected Acute Coronary Syndrome

Age range

45 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

St. Luke's and Roosevelt Hospitals

New York, 10025, United States

About this study

Currently, physicians can either choose a stress test or a CT scan of the heart to evaluate patients admitted with with chest pain. Very little is known about which test provides the best information to physicians, positively impacts patients medical care, and decreases future hospital admissions and testing. To study this the investigators are randomizing patients admitted to our hospital with chest pain to a stress test or coronary CT angiography. The investigators will then follow these patients for a 2 year period.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with chest pain or SOB admitted for rule out acute coronary syndrome
  • Age ≥45 years
  • EKG non-diagnostic for acute coronary syndrome
  • At least 1 set of negative troponin I

Exclusion criteria

  • Patient with ST elevation myocardial infarction.
  • Patients with non-ST elevation myocardial infarction.
  • Patients with known CAD.
  • Patients with serum creatinine > 1.5.
  • Atrial fibrillation or marked irregular heart rhythm.
  • Patients in whom heart rate cannot be controlled.
  • Patient with allergies to iodinated contrast agents.
  • Pregnant women
  • Patients unable to give informed consent

Treatment and study plan

Coronary CT Angiography

Procedure

CCTA

Stress Test

Procedure

Stress Test

Primary outcomes

  1. Time to discharge

    Time frame: Initial hospitalization

  2. Change in medical regimen

    Time frame: Initial hospitalization

  3. Downstream cardiovascular testing and hospitalization

    Time frame: 2 years

Secondary outcomes

  1. All-cause mortality

    Time frame: 7 days, 30 days, 6, 12, and 24 months.

    This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain.

  2. Cardiovascular mortality

    Time frame: 7 days, 30 days, 6, 12, and 24 months.

    This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain.

  3. Non-fatal myocardial infarction

    Time frame: 7 days, 30 days, 6, 12, and 24 months.

    This measure is to ascertain if CCTA and stress testing can be used safely as the initial test in patients admitted to the hospital with chest pain.

Sponsors and collaborators

Lead sponsor

St. Luke's-Roosevelt Hospital Center

Other

Registry information

Official study title

ProspEctive Randomized First Evaluation in Chest Pain Trial

Acronym: PERFECT

Important dates

Study start
2011
Primary completion
2013
Study completion
2015
First posted
May 24, 2012
Registry last updated
Mar 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.