Prospective Evaluation of Breast Cancer at Brazilian Institutions - Project AMAZONA III

The principal goal of this study is to describe the epidemiology of breast cancer in the Brazilian population. Other specific goals are:

• To evaluate the demographic and socio-demographic profile, comorbidities and reproductive risks, anthropometric profile and family history.
• Characterize the breast tumors immunophenotype through anatomopathological data, such as: tumor grade, estrogen receptor, progesterone receptor, HER2, Ki67.
• Describe the screening tests, main symptoms and cancer stage in the moment of the diagnosis.
• Describe the initial cancer treatment and locally advanced such as surgery, radiotherapy, chemotherapy and endocrine therapy.
• Describe palliative treatment for recurrent or metastatic breast cancer: chemotherapy, radiotherapy, biphosphonate, and others.
• Evaluate the clinical outcomes such as: local or diffuse relapse, period of time until progression to metastatic cancer, global lifespan and specific breast cancer lifespan.
• Evaluate clinical complications of the metastatic disease, such as: brain metastasis, spinal cord compression, skeletal related events.
• Analyze the demographical and socio-economical characteristics, clinical-pathological characteristics of the tumor, treatment, clinical outcomes, type of institution (private/public), and other factors that may impact clinical outcome.

Inclusion criteria

• Woman ≥ 18 years old
• Invasive breast cancer stage I to IV proven by histology or cytology
• Patients with new pathological diagnosis of invasive primary BC after the site activation date
• Pathological diagnosis of invasive breast cancer during recruitment (6 months before center activation or until 3000 patients included)
• New primary cancer on the same breast or contralateral breast.
• Patient's medical chart is available and adequate for data collection
• Patient properly signed the informed consent form