Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients.

Completed

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Key information

Conditions

HIV Infections AIDS-Related Opportunistic Infections Acquired Immunodeficiency Syndrome Bacterial Infections Bacterial Infections and Mycoses Blood-Borne Infections Communicable Diseases Enterobacteriaceae Infections Genital Diseases Gram-Negative Bacterial Infections Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections Opportunistic Infections RNA Virus Infections Retroviridae Infections Salmonella Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Urogenital Diseases Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Los Angeles County - USC Med Ctr

Los Angeles, California, 90033, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

Co-existing Condition:

Patients with the following are excluded:

Type I hypersensitivity to beta-lactam antibiotics.
Not expected to survive 12 weeks.
In a coma or with other central nervous system (CNS) impairment.

Patients with the following are excluded:

Type I hypersensitivity to beta-lactam antibiotics.
Not expected to survive 12 weeks.
In a coma or with other central nervous system (CNS) impairment.

Prior Medication:

Excluded within 48 hours of study entry:

Treatment with an antibiotic active in vitro against Salmonella.

HIV infection, AIDS, or AIDS related complex (ARC).

Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.

Treatment and study plan

ceftriaxone sodium

Drug

Ampicillin sodium

Drug

Amoxicillin trihydrate

Drug

Sponsors and collaborators

Lead sponsor

University of Southern California

Other

Registry information

Important dates

First posted: Aug 31, 2001
Registry last updated: Jun 24, 2005

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed