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NCT Number: NCT07705997

Prospective Cohort Study of Aging in Patients With Acute Myocardial Infarction

This is a single-center, prospective, observational cohort study designed to investigate the association between aging-related characteristics and long-term outcomes in patients with acute myocardial infarction (AMI). Approximately 588 eligible participants will be consecutively enrolled and followed for at least 24 months. Clinical data, aging assessments, laboratory examinations, cardiac imaging, and blood samples will be collected to establish a clinical database and biobank. The study aims to identify aging-related prognostic biomarkers, develop a risk prediction model integrating clinical and aging-related indicators, and improve risk stratification and individualized management for patients with AMI.

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Key information

Conditions

Acute Myocardial Infarction (AMI)

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1. Age ≥ 60 years old and meet the above comprehensive aging assessment criteria (i.e., combined with at least one clinical phenotype of aging and abnormal blood aging markers on the basis of advanced age); 2. Acute myocardial infarction occurs for ≥ 3 months; 3. Meet the diagnostic criteria for AMI in accordance with the Fourth Edition General Definition of Myocardial Infarction; 4. The patient or their legal representative signs an informed consent form.

Exclusion criteria

  • 1. Newly diagnosed acute myocardial infarction, angina pectoris, stroke or transient ischemic attack within the past 3 months; 2. Serious life-threatening diseases (such as advanced malignant tumors, end-stage kidney disease/liver disease, severe infections) with an estimated lifespan of less than 1 year; 3. Severe cognitive impairment, mental illness, inability to cooperate in completing follow-up, aging assessment, and related examinations; 4. Unable to complete assessment items such as grip strength, walking speed, and 6-minute walk test due to non cardiac reasons such as physical disabilities and severe bone and joint diseases; 5. Failed to sign the informed consent form.

Treatment and study plan

Primary outcomes

  1. Major adverse cardiovascular events (MACE)

    Time frame: Baseline through 24 months of follow-up

    The occurrence of major adverse cardiovascular events, including all-cause death, cardiovascular death, recurrent myocardial infarction, hospitalization for heart failure, stent restenosis or thrombosis, severe bleeding, and aging-related serious adverse events.

Secondary outcomes

  1. All-cause mortality

    Time frame: Baseline through 24 months

    Death from any cause during follow-up.

  2. Cardiovascular mortality

    Time frame: Baseline through 24 months

    Death attributable to cardiovascular causes, including sudden cardiac death, heart failure, or cardiogenic shock.

  3. Hospitalization for heart failure

    Time frame: Baseline through 24 months

    Hospital admission due to worsening heart failure requiring intravenous diuretics, inotropic agents, or vasoactive therapy.

  4. Recurrent myocardial infarction

    Time frame: Baseline through 24 months

    New acute myocardial infarction occurring during follow-up according to standard diagnostic criteria.

  5. Aging-related serious adverse events

    Time frame: Baseline through 24 months

    Aging-related adverse outcomes, including cognitive decline, frailty-related fracture after low-energy falls, or loss of activities of daily living.

  6. Prognostic performance of the aging-related risk prediction model

    Time frame: At completion of the 24-month follow-up

    Predictive performance of the prognostic model integrating clinical characteristics, aging assessments, and aging-related biomarkers, evaluated using discrimination and calibration metrics.

Study contacts

Contact information is provided by the study sponsor or research team.

Mingwei W Wang, PhD

CONTACT

[email protected]

18758871517 ext. not

Sponsors and collaborators

Lead sponsor

The Affiliated Hospital of Hangzhou Normal University

Other

Registry information

Official study title

A Single-Center, Prospective, Observational Registry Cohort Study to Investigate Aging-Related Biomarkers, Prognosis, and Risk Prediction in Patients With Acute Myocardial Infarction

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Jul 15, 2026
Registry last updated
Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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