Prospective Cohort of Patients With Systemic Sclerosis at Brest University Hospital With Biobanking

To assess whether age correlates with disease profile and progression

To assess whether sex correlates with disease profile and progression

To assess whether weight correlates with disease profile and progression

To assess whether medical history predicts the pattern and course of the disease

To assess whether family history predicts the pattern and course of the disease

This score evaluates the thickness of the skin from 0 to 51. 0 meaning the absence of scleroderma (the healthiest score) and 51 completely sclerotic skin (the worst possible score)

4 characteristics must be taken into account:

• the type of ulcer: mechanical/on calcinosis/ischemic
• the recent/semi-recent/chronic character,
• the painful character or not,
• the total number of fingers affected on the 10 fingers.

• stage I: absence of dyspnea for usual efforts: no discomfort is felt in everyday life,
• stage II: dyspnoea for usual heavy exertion, such as brisk or hill walking or climbing stairs (≥ 2 floors),
• stage III: dyspnea for low intensity efforts of everyday life, such as walking on flat ground or climbing stairs (< 2 floors),
• stage IV: permanent dyspnea at rest or for minimal effort (putting on a garment, for example)

Free Carbon Monoxide Diffusion (DLCO) in percentage.

Distance (in meters) covered in the 6-minute walk test.

Measured on cardiac ultrasound.

The SF-36 is an indicator of health status and quality of life. The SF-36 has eight dimensions; the scores are weighted sums of the questions in each section. This scores range from 0 - 100. Lower scores indicate more disability and higher scores less disability.

The eight dimensions of this score are:

• Vitality
• Physical functioning
• Bodily pain
• General health perceptions
• Physical role functioning
• Emotional role functioning
• Social role functioning
• Mental health

A quick and easy way to measure the intensity of pain and its impact on daily activities. Patients rate the maximum, minimum, average and current intensity of their pain and the influence of pain on seven aspects of functional ability. 3 scores are obtained between 0 and 10, with 10 corresponding to :

• the worst pain experienced in the last 24 hours
• the highest pain intensity combining the most intense, the least intense, the average pain and the pain experienced at the time of the questionnaire
• the highest interference of the pain on daily activities

Evolution of HAQ-DI (Health Assessment Questionnaire - Disability Index) during follow-up 8 fields questionnaire (DRESSING & GROOMING, ARISING, EATING, WALKING, HYGIENE, REACH, GRIP, Other activities), scaled from 0 to 3, 3 meaning a worse outcome