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NCT Number: NCT05164328

Prospective Athlete's Heart Study

The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.

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Key information

Conditions

Athlete Heart Arrhythmias, Cardiac Atrial Fibrillation Cardiomyopathies Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

14 year–23 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males and females aged 14-23 years old
  • Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:
  • Triathlon
  • Cycling
  • Distance running (≥ 1500 meters)
  • Rowing
  • Swimming
  • Non athletes engaged in < 3 hours per week of physical activity

Exclusion criteria

  • Medical history of cardiovascular disease
  • Current smoker of past history of smoking
  • Diabetes mellitus

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

  1. Genotype

    Time frame: Baseline

    Rare and common variants in cardiomyopathy associated genes

  2. Training load

    Time frame: Baseline to 20 years

    Duration and intensity of training

  3. Atrial fibrillation

    Time frame: Baseline to 20 years

  4. Ventricular arrhythmias

    Time frame: Baseline to 20 years

    Ventricular ectopic beats, non-sustained and sustained ventricular tachycardia

Study contacts

Contact information is provided by the study sponsor or research team.

Guido Claessen, Prof. Dr.

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Universitaire Ziekenhuizen KU Leuven

Other

Collaborators

  • Baker Heart and Diabetes Institute
  • Jessa Hospital
  • University Hospital, Antwerp
  • Victor Chang Cardiac Research Institute

Registry information

Official study title

Prospective Athlete's Heart Study: Long-term Assessment of the Determinants of Cardiac Remodelling and Its Clinical Consequences in Endurance Athletes

Acronym: Pro@Heart

Important dates

Study start
2015
Primary completion
2035
Study completion
2040
First posted
Dec 20, 2021
Registry last updated
Dec 20, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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