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NCT Number: NCT05183971

Proprioceptive Deficits in Degenerative Cervical Myelopathy

Proprioceptive deficits in degenerative cervical myelopathy (DCM) is a progressive neurological deficits in somatosensory and motor function which affects the body balance and motor control. DCM usually presents with body incoordination, hand clumsiness and gait disturbance associated with proprioceptive dysfunction that hinders the physical performance and functions. In this study, a non-invasive assessment protocol on proprioception will be developed for detecting subtle proprioceptive deficits at the early stage of disease through simple Physical Performance Tests for population older than 45. By adopting the physical performance tests as the diagnostic predictors of DCM, we aim to avoid the development of devastating consequences and disabilities.

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Key information

Conditions

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Duchess of Kent Children's Hospital at Sandy Bay

Hong Kong, 000

Location status: Recruiting

Location contact

Karlen Ka Pui Law, M. Phil

CONTACT

[email protected]

852-29740531

About this study

DCM is a chronic insidious disease, one of the most disabling orthopaedic conditions, which involves compression of the spinal cord by the surrounding structures in cervical spinal region. It characterizes with progressive neurological deficits in body coordination, hand clumsiness and gait disturbance as the preliminary symptom which may cause by proprioceptive dysfunction .

Physical performance and function hinder patients' hand clumsiness, gait disturbance and body imbalance. The incoordination between body, upper limbs and lower limbs will be resulted from proprioceptive deficits caused by spinal cord compression. By adopting the Proprioceptive Functional Analysis System (PFAS), proprioceptive deficits over the core body joints and peripheral joints could be tested during Activity of Daily Living (ADL) with reference to normal subjects' performance. All subjects will be tested by the PFAS and Physical Performance Tests.

The idea of regional proprioceptive deficit will be incorporated in the assessment protocol for DCM to facilitates a breakthrough from the traditional DCM functional evaluation.

In developing a non-invasive assessment protocol to assess proprioceptive deficit, we aim to detect subtle proprioceptive deficit from the tests, especially at the very early stage of disease. We target to demonstrate the validity of Physical Performance Tests are evenly high as that of the advanced technology, PFAS.

Consequently, by adopting the valid Physical Performance Tests in health screening scheme for population older than 45 within the community can serve as an early diagnostic parameter of DCM and avoid delayed treatment leading to devastating consequences and disabilities.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chinese
  • Aged 50 or above
  • With radiological evidence of degenerative cervical myelopathy, both symptomatic and asymptomatic
  • Nurick grade less than 3

Exclusion criteria

  • Non-Chinese ethnicity
  • Aged under 50
  • without any radiological proof of cervical myelopathy
  • Active problems of tuberculosis spine, lumbar spinal diseases, and other problems causing pain or deformities over the limbs that may affect their balance and movement
  • Presents with extra-pyramidal or other disorders involving the cerebellum or frontal lobe of the cerebrum leading to poor balance and gait disturbance
  • Previous spinal operation with residual disturbance in balance or gait
  • Non-communicable patients with insufficient cognitive ability to express their symptoms clearly
  • Non-walker
  • Blind or deaf

Treatment and study plan

Proprioceptive Functional Analysis System

Other

Proprioceptive testing and Physical Performance Tests

Primary outcomes

  1. Modified Japanese Orthopaedics Association Scoring System for Cervical Myelopathy (mJOA)

    Time frame: 15 years

    mJOA is a self-reported functional questionnaire on disease severity through assessing 4 domains:

    • Upper Limb Function
    • Lower Limb Function
    • Sensory Function
    • Bladder Function

    mJOA has a total score of 17 and it categories DCM patient into different severity as below:

    • Mild >= 15
    • Moderate = 12-14
    • Severe < 12

Secondary outcomes

  1. Proprioceptive Deficits - Speed Test

    Time frame: 15 years

    Proprioceptive deficits hinder the limb coordination, especially the fine finger dexterity, reciprocal walking and stepping. Thus, incoordination over the lower and upper limbs will then be resulted and which alters the speed and integrity of the performance in the Physical Performance Tests validated for DCM.

    In the physical performance tests, it has divided into 2 separate sections, the "Speed Test" will be recorded for in terms of the "Time required to complete" the standardized test process in seconds

  2. Proprioceptive Deficits - Time Limited Test

    Time frame: 15 years

    Time Limited Test of physical performance test will be assessed and data will be recorded in terms of "Total number of repetitions completed" within strictly fixed time frame

Study contacts

Contact information is provided by the study sponsor or research team.

Karlen Ka Pui Law, M. Phil

CONTACT

[email protected]

852-29740531

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Registry information

Official study title

Early Detection of Proprioceptive Dysfunction in Degenerative Cervical Myelopathy by Proprioceptive Functional Analysis in Activities of Daily Living

Important dates

Study start
2022
Primary completion
2040
Study completion
2046
First posted
Jan 11, 2022
Registry last updated
Jun 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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