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NCT Number: NCT07665814

Propolis-Based Solution Application in Extraction Socket Healing

This pilot study evaluated whether a propolis-based topical solution improves soft-tissue healing after tooth extraction. Thirteen patients requiring extraction of two comparable teeth on opposite sides of the mouth were enrolled in a split-mouth design, in which one extraction site received the propolis solution while the other served as an internal control. The test site was treated with the propolis solution three times daily for seven days, while the control site received only saline rinses. Healing was tracked using 3D intraoral scans obtained before extraction and on days 7 and 14 afterward, allowing the percentage of socket closure to be measured objectively over time. Postoperative pain was also assessed using a standard visual pain scale on days 1, 3, and 7. The study aimed to determine whether this propolis-based formulation could serve as a natural, low-cost adjunct to standard post-extraction care to support faster tissue repair.

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Key information

Conditions

Healthy

Age range

8 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Saint Joseph University of Beirut

Beirut, Lebanon

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cooperative adult patients willing to accept the study protocol
  • Minors with a cooperative parent/legal guardian providing consent
  • Non-surgical extraction of bilaterally positioned teeth
  • Low-to-moderate extraction difficulty per the Pederson scale
  • Systemically healthy, with no history of systemic disease

Exclusion criteria

  • Non-consenting patients
  • Failure to attend follow-up appointments per protocol
  • Heavy smokers (>10 pack-years)
  • Systemic disease (e.g., diabetes mellitus, immunosuppressive syndromes)
  • Current use of contraceptive medication
  • Systemic antibiotic therapy within the previous 3 months
  • Anticoagulant therapy within the previous 4 weeks
  • Requirement for antibiotic prophylaxis
  • Pregnant or breastfeeding women
  • Known allergy to honey or bee-related products
  • Known allergy to local anesthetics used in dental procedures
  • Higher-difficulty extractions requiring sutures or other hemostatic measures

Treatment and study plan

Propolis-based topical solution (52% propolis extract, clove oil [Eugenia caryophyllus], and white willow bark [Salix alba] extract)

Drug

Drug: Propolis-Based Solution

"A topical solution (52% propolis extract, clove oil, and white willow bark extract) applied to the test extraction socket via brush applicator three times daily for seven days."

Saline rinse (control)

Other

The contralateral extraction socket received saline mouthwash only, with no active therapeutic agent applied, following the same pre-application oral hygiene steps (tooth brushing and saline rinse) as the test site

Primary outcomes

  1. Percentage of Extraction Socket Surface Area Closure

    Time frame: Baseline (Day 0), Day 7, and Day 14 post-extraction

    Percentage reduction in socket surface area from baseline, calculated from 3D intraoral scans using the formula: % Closure = (Baseline area - Timepoint area) / Baseline area × 100.

Secondary outcomes

  1. Postoperative Pain Score

    Time frame: Day 1, Day 3, and Day 7 post-extraction

    Pain intensity rated on a 10-cm Visual Analog Scale (VAS), with higher scores indicating greater pain.

Sponsors and collaborators

Lead sponsor

Saint-Joseph University

Other

Registry information

Official study title

Propolis-Based Solution Application in Extraction Socket Healing: A 3D Split-Mouth Clinical Pilot Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 24, 2026
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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