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Completed

NCT Number: NCT05290324

Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery

Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

20 year–20 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ch. Pervaiz Elahi Institute of Cardiology

Multan, Punjab Province, 59341, Pakistan

About this study

Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease "ventilator-asynchrony" in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of American Society of Anesthesiologists (ASA) III who were selected for coronary artery bypass graft surgery.

Exclusion criteria

  • History of any psychiatric disease.
  • Using antidepressants
  • Alcohol abusers
  • Obese
  • Pregnant women

Treatment and study plan

midazolam

Drug

Midazolam infusion will be given after the surgery as 0.25 mg/kg/min.

Other names: Versed

Primary outcomes

  1. Duration of post-surgery sedation

    Time frame: Time in minutes calculated from end of surgery to the time of awakening up to 24 hours in both study groups

    Duration of post-surgery sedation following cardiac surgery

  2. Time taken to post-surgery extubation

    Time frame: Time taken in minutes from the end of the cardiac surgery to post-surgery extubation up to 1 week duration in both study groups

    Time taken from the end of cardiac surgery to post-surgery extubation

Sponsors and collaborators

Lead sponsor

Chaudhry Pervaiz Elahi Institute of Cardiology

Other Gov

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Mar 22, 2022
Registry last updated
Mar 22, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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