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NCT Number: NCT07022730

Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension

researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension

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Key information

Conditions

Post Induction Hypotension Cardiovascular Diseases Hypotension Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome Vascular Diseases

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cairo University

Cairo, Cairo Governorate, 6890, Egypt

About this study

If post-induction hypotension is not addressed promptly, it can lead to severe complications such as reduced blood flow, acute kidney damage, and myocardial ischemia. As a result, early detection and proactive intervention are crucial. Researchers of the current study decided to investigate impact of noradrenaline administered as a prophylaxis on post induction hypotension

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients with sepsis undergoing source control surgery.

Exclusion criteria

  • Patient refusal
  • Patient with cardiac pathology ( ischemic heart disease or heart failure)
  • Preoperative hemodynamic instability (defined as MAP < 65 mmHg)
  • Rapid sequence induction

Treatment and study plan

Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction

Drug

noradrenaline will be given at a rate of 0.2 mcg/kg/min that will start 5 minutes before induction

Primary outcomes

  1. Incidence of post induction hypotension in both groups

    Time frame: Within the first 10 minutes of induction.

    Hypotension will be considered if MAP< 65 mmHg

Secondary outcomes

  1. Incidence of acute kidney injury

    Time frame: 7 days post operative

    defined as the highest postoperative value > 1.5-fold or 0.3 mg/dL greater than the preoperative value

  2. Incidence of myocardial infarction

    Time frame: 7 days postoperative

    defined as a peak troponin T value exceeding 15 times the normal upper limit, along with new pathological Q waves, ST elevation or depression, and hyperacute T wave on ECG and symptoms suggestive of myocardial infarction

  3. Incidence of stroke

    Time frame: 7 days postoperative

    clinical or image finding of stroke

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

The Novel Use of Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension in Patients With Surgical Sepsis, a Double Blind Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 15, 2025
Registry last updated
Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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