Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries

The usual symptoms of PDPH other than headache are photophobia, neck stiffness, nausea and vomiting, diplopia, tinnitus, and dizziness. The headache is usually throbbing and severe, starting from the forehead and extending to the occiput, and is aggravated by standing or sitting. This is due to meningeal traction associated with cerebrospinal fluid (CSF) pressure reduction or dilation of cerebral arteries as an indirect effect of lowering CSF pressure as a result of CSF leakage from the punctured dura. Current treatments or preventive measures for PDPH other than bed rest and hydration include theophylline, sumatriptan, caffeine, etc. In resistant or severe cases, epidural blood patch (EBP) is a well-described technique used to provide relief of pain.

The co-administration of neostigmine and atropine is a common treatment for terminating the effects of non-depolarizing muscle relaxants in the setting of general anesthesia with minimal side

Inclusion criteria

• BMI less than 35 kg/m2
• Scheduled for infraumbilical surgeries
• American Society of Anesthesiologists (ASA) physical status: I and II

Exclusion criteria

• ASA physical status more than II.
• History of allrgic response to local anaesthetics or any of the medications used in the study
• Patients with cognitive impairment
• pregnancy
• Basal body temperature of more than 38°C or less than 36°C
• BMI more than 35 kg/m2